What if I told you I believe that iPS cells really began in Seattle in the 1980s? Call me crazy? Read on. We hear a lot about how iPS cells were first created in 2006 in Japan by Shinya Yamanaka. I often say this myself. However, as is the case with so much in science, […]
How iPS cells germinated in part in Seattle in the 1980s Read More »
What are the most important iPS cell papers so far? 1) Yamanaka’s first paper on mouse iPS cells. Revolutionary. Intriguing perspectives presented in day 1 of the iPS cell field. Interesting statements such as Myc is required. Also take a look at those other reprogramming factors that he tested…there’s a tremendous amount there, largely unexamined.
What are the best iPS cell papers so far? Read More »
Do we still need iPS cells if transdifferentiation is so cool? Wait, how did we get to the point that people are asking me that extreme question? When iPS cells were first introduced to the world by Shinya Yamanaka, who I think will win the Nobel Prize sometime in the next few years, some folks went
Transdifferentiation does not make iPS cells obsolete Read More »
I have posted before about publishing trends in the iPS cell field here and in here…. but where do things stand today? Here, I provide an important update. What’s going on now? Here I provide answers to the key questions. How many papers are there on iPS cells? An interesting and unexpected trend for
Everything you need to know about publishing in the iPS cell field Read More »
Periodically we do updates on the iPS cell field and now seems like a good time. Where do things stand? Here’s my top 5 list of action items for the iPS cell field in the coming year. 5.) Methods on the brain. A significant fraction, some would argue too high a fraction, of iPS cell
Key iPS cell action items Read More »
You can pick more than one in our poll on the induced pluripotent stem cell (iPS cell) method that you prefer.
Poll on iPS cell method Read More »
Yamanaka may have found a way to give exogenous Myc the boot from the iPS cell universe. It has always been a frustration in the iPS cell field that Myc, a proto-oncogene, is so important for reprogramming. Yes, you can make iPS cells (especially mouse) without Myc, but it can be orders of magnitude harder,
New iPS cell method: drop Myc or not yet? Read More »
Today is Friday the 13th, which is supposed to be bad luck, and it seems to be a bad luck day for iPS cells. A paper came out today in Nature that will be highly upsetting for anyone hoping that iPS cells can follow a fairly direct path to the clinic. The paper from Yang
Friday the 13th for iPS cells Read More »
Yesterday I ran a cancer stem cells meeting here at UC Davis School of Medicine. We had some great speakers and over 150 participants including our outstanding keynote speaker, Dr. Jeremy Rich, Director of Stem Cell Research at the Cleveland Clinic. One of the ideas percolating through the meeting was that during cancer development, there
Cancer stem cells and iPS cells Read More »
What are iPS cells? We talk about iPS cells all the time. We are very excited about them. Heck, the web address for this blog is ipscell.com. But what are iPSCs, really? iPS cells definition A simple definition of iPSCs is the following: Embryonic stem cell-like cells that are made from non-stem cells in a
An insider’s guide: what are iPS cells? Read More »