organoids

Weekly science reads: Macchiarini trial, somites, CRISPR babies

organoids with somites, cool science

This has been one of those weeks where I spent some time thinking about taking risks in science. How much risk one should take? Risks can come in many forms. It could be at the core level at the bench doing specific experiments and not others. There’s risk in clinical trials, and even in advocacy. Sometimes …

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Top stem cell stories of 2021: COVID, diabetes, human embryos, clinics in court

regenerative medicine, stem cells 2021

The past year was all over the place for the stem cell and regenerative medicine field. As you can see in my scoring of my 21 predictions for 2021, quite a few things were surprises in terms of what did and didn’t happen. Here’s an overview of the top stories of the year in our …

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A look at “eyes on the brain organoids” Cell Stem Cell paper

brain organoids eyes

Sometimes a paper really catches your eye like a new Cell Stem Cell pub reporting eye-like structures grown on brain organoids. The paper is Human brain organoids assemble functionally integrated bilateral optic vesicles. Let’s take a quick look at this paper, its context, and the potential big-picture implications. Brain organoids with “eyes”? At first glance, …

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Weekly reads: badgers, organoids, The Onion, & more

A badger in Yellowstone Park. Photo Paul Knoepfler. Could you make organoids from one?

It’s been a little quiet here on The Niche for the past week as I was off in Yellowstone National Park, but I’m back with this week’s recommended weekly reads including a section on organoids. First, I want to share a nature pic from the trip. A highlight was encountering a badger in Lamar Valley …

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Weekly reads: embryo pubs stir things up, organoids crying, & more

organoids tear glands sm

This was an unusual week in that three papers in a sense collided together related to embryo production and growth, raising new research possibilities but also serious ethical questions. New research: what is an embryo & what is not? The first two Nature papers reported generating the most realistic models of human embryos from scratch …

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Dissecting that Neanderthal brain organoids Science pub

neanderthal human brain organoids

Organoids and especially brain organoids, which are made from pluripotent stem cells, are one of the most interesting developmental biology technologies of the last half a dozen or so years. Still some folks can’t help but get carried away when thinking about brain organoids it seems. A new Science paper from a team led by …

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Regenerative reads: pig fat, cancer, organoids, more

Chen-et-al-STM-2020-7a-fat-stem-cells-bone-sm

It’s usually a tossup as to whether my weekly reads skew more towards stem cells/regenerative medicine or cancer. Other times they are more enriched for genomics and epigenetics articles. Seeds of cancer in normal skin, Nature News & Views Engineering synthetic morphogen systems that can program multicellular patterning, Science. Pig fat can be used to …

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Groundbreaking Organoid Vision Clinical Study: Takahashi Q&A

Mandai-et-al-Stem-Cell-Reports-2017

Clinical trials using organoids are still rare and a Clinicaltrials.gov search for such organoid work largely brings up in vitro studies. A new clinical study in Japan where organoid material will actually be transplanted into patients is causing a lot of excitement. Masayo Takahashi (高橋 政代) is a pioneer in stem cell-based clinical trial work …

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Weekly reads: organoids, COVID-19, CIRM & cool new pubs

Human-intestinal-organoids-infected-with-SARS-CoV-2-white.-Credit-Joep-BeumerClevers-groupHubrecht-Institute

Organoids are providing a novel avenue into the pathogenesis of COVID-19 and novel models for drug screening. A number of new preprints on respiratory organoids shed new light in this area. They were highlighted in a Nature newsy piece, Mini organs reveal how the coronavirus ravages the body. It’s a challenge to study COVID-19 infections because just infecting …

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20/20 vision? The Niche’s 20 stem cell & regenerative medicine predictions for 2020

The-Niche-stem-cell-predictions-2020

Every year in December and early January I do a post predicting some key events for the stem cell and regenerative medicine field for the upcoming year and today’s post contains my predictions for 2020. You can see my past 2019 predictions along with my grades for them here. I gave myself a B+ for …

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