Search Results for: yamanaka

Why miRNA iPS cells might be the ticket: an A+ paper

  Since Yamanaka’s discovery of iPS cells first in mouse and then in human cells 5 years ago, both made using viral transduction, a host of new methods to make iPS cells have been reported.  These methods are quite diverse, ranging from transposons, to recombinant proteins, to plasmids, and to RNA.  Often times these new …

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Who’s who in iPS cells: scientists, journals, funding agencies, countries, and biotechs

Who’s who in the iPS cell field?  In this post, I examine the people, journals, places, funding agencies, and companies that are the leaders in the iPS cell field. I start with publishing. Last year we did a post on publishing trends in the iPS cell field.  It suggested that the iPS cell field was exploding …

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Will America be 2nd rate for research?

Stem cell research is a truly global endeavor. How will America’s role evolve in this field and other areas of biomedical research? Because of politic, legal, and budgetary reasons, there are growing concerns that the U.S. may find itself 2nd rate for stem cell research and perhaps also for other fields of science as well. …

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The Inside Scoop on iPS cells early in 2011

It’s been more than 4 years since Shinya Yamanaka published the remarkable finding that his lab could transform or “reprogram” regular cells called fibroblasts into a very unique state that was quite similar to that of embryonic stem cells (ESC).  Yamanaka called these new cells “iPS cells” for induced pluripotent stem cells. Since that time, …

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From Point A to Point Z: thinking outside the box about stem cells

What is the best way to get new stem cell-based therapies to the millions of patients who need help? I would argue that this is the key question in the field of stem cell biology and regenerative medicine. Sometimes I think it is easy for folks to lose sight of that and fall into traps. …

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Anonymous stem cell scientist frankly answers questions about the field

Anonymous-scientist-stem-cell-field

Here an anonymous stem cell scientist frankly answers questions about the field in an interview with me. Of course I have to ask you about the recent U.S. court ruling essentially declaring all federal funding of human ES cell work illegal. What’s your take on this? ANSWER: The ruling has so many flaws in it. …

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Tumorigenicity and Pluripotency teased apart? Not yet for Myc

Fig.-5-Nakagawa-et-al.-Myc-in-cancer-and-IPScs

A paper just came out in PNAS entitled “Promotion of direct reprogramming by transformation-deficient Myc“. The main thrust of this paper is that the tumorigenic and pluripotency-related functions of Myc could be separated. It focused primarily on the lesser studied LMyc. The topic of the intertwined good (pluripotency) and bad (tumorigenicity) functions of Myc, addressed …

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