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CAR-T cells review: cancer & a critical look at possible uses in aging & COVID-19

September 3, 2020 / Suhas Sakamuri / 2 Comments

Introduction to CAR-T cells CAR-T cells are an exciting cutting-edge technology that has been garnering great interest including in the stem cell field. Potential therapeutic uses of CAR-T, which stands for Chimeric Antigen Receptor T-Cells (CAR-T), are being studied in clinical trials as immunotherapies to potentially fight cancer as well as many other diseases by

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FTC fires off many warnings to stem cell clinics on COVID-19

September 1, 2020 / Professor Paul Knoepfler, Ph.D. / 7 Comments

BioXcellerator-warned-by-FTC-over-stem-cells-for-COVID-19-has-many-promotional-videos.-This-is-a-screenshot-from-one.

The FTC has sharply increased its oversight activities against stem cell and regenerative clinic firms. These new actions include quite a few warning letters. Here is the FTC database for COVID-19-related warning letters. Note that recently the FTC added a new, helpful option to view all of its warning letters here. It’s a good source

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Politics & FDA OK of 2 stem cell clinic COVID-19 efforts

August 24, 2020 / Professor Paul Knoepfler, Ph.D. / 5 Comments

The FDA and its CBER branch have been doing a good job overall in the last 3+ years to tackle the unproven stem cell clinic problem, but lately on the stem cells for COVID-19 front there is reason for real concern. I believe the agency is taking on major risk overall by clearing a vast number of

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Overselling stem cells for COVID-19: WSJ article & UMN PR

August 18, 2020 / Professor Paul Knoepfler, Ph.D. / 13 Comments

Many are jumping on the bandwagon of trying stem cells for COVID-19 or testing other cellular therapies for the novel coronavirus disease, but there have been problems with either the rationales for the trials themselves or more often with how they portrayed. Sometimes there has even been outright hype. I’ve called this collective trend of

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Weekend recommended reads: Athersys, ALS, COVID-19, Fibroblasts, Zoom brain

August 9, 2020 / Professor Paul Knoepfler, Ph.D. / 3 Comments

What are you reading these days and does it include topics like cell therapies for COVID-19, ALS, regenerative potential of fibroblasts, and why Zoom meetings are so tiring for the brain? I cover those topics and more below with recommended reads including papers and media items. Here’s last week’s recommended reads. Here’s to fibroblasts, which

Review of 4 cell therapy types under study for COVID-19

August 3, 2020 / Mina Kim / 9 Comments

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This is a post by Mina Kim, a UC Davis student intern for The Niche blog, about the main types of cellular therapies being studied clinically for COVID-19. During the novel coronavirus pandemic with millions of COVID-19 cases, the development of safe and effective treatments for patients is vital. Cellular medicine treatments are one of

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Rick Perry plugs Celltex MSCs on Fox for COVID-19 prevention

July 2, 2020 / Professor Paul Knoepfler, Ph.D. / 10 Comments

Rick-Perry-plugging-Celltex-stem-cells-on-Fox-News

Why is former Texas Governor/Trump Energy Secretary Rick Perry plugging unproven stem cells from a clinic firm called Celltex for COVID-19 prevention on Fox News? Perry follows in Giuliani’s footsteps? And more generally, what is it with conservative politicians promoting unproven therapies for COVID-19 and in particular stem cells for the novel coronavirus disease? First,

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BARDA drops funding of research into stem cells for COVID-19

June 29, 2020 / Professor Paul Knoepfler, Ph.D. / 14 Comments

Katie Thomas at the New York Times reports that BARDA has dropped considering funding applications for stem cells for COVID-19. The move is part of a larger shift in funding priorities away from lung treatments and toward vaccine development. The decision has puzzled and even angered some stem cell firms and researchers. BARDA stands for

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Recommended regenerative medicine reads: COVID-19 updates, Cornea Fix, Pubs