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Live Blogging #GeneEditSummit Day 1 Post #4: Societal Implications of human gene editing

December 1, 2015 / Professor Paul Knoepfler, Ph.D. / 4 Comments

This is post #4 of my live blogging of the #GeneEditSummit today. It is focused on societal implications so I’m really looking forward to it. You can read posts 1-3, here, here, and here summarizing the talks and key points from the meeting so far. Annelien L. Bredenoord, University Medical Center Utrecht, chaired the session. John Harris, […]

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Live Blogging NAS Human Gene Editing Summit: #GeneEditSummit

November 28, 2015 / Professor Paul Knoepfler, Ph.D.

The National Academy of Sciences (NAS) summit on Human Gene Editing will begin in a few days on December 1 in Washington, D.C. This summit is in part the extension of discussions that started at a more informal meeting on CRISPR earlier this year in Napa organized by Jennifer Doudna and colleagues. The NAS meeting

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NAS Human Gene Editing Meeting: Agenda & Public Participation

October 26, 2015 / Professor Paul Knoepfler, Ph.D. / 1 Comment

A draft agenda is now publicly available for the upcoming National Academy of Sciences (NAS) meeting on human gene editing. We now know a lot more about what to expect from this international gathering, which is called the International Summit on Human Gene Editing: A Global Discussion. The meeting will start on day 1 with

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List of Speakers for NAS Meeting on Human Gene Editing

October 1, 2015 / Professor Paul Knoepfler, Ph.D. / 4 Comments

Who will be speaking at the upcoming National Academy of Sciences (NAS) meeting on human gene editing? So far we haven’t known, but now we do (if you are eager to find out, skip to bottom of the post). The organizers of the meeting can be found here. Keep in mind that it is probable that

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Public polling on human gene editing, moratorium

May 21, 2015 / Professor Paul Knoepfler, Ph.D. / 1 Comment

Many of us scientists, ethicists, and legal scholars are working on educational outreach to the public on the potential use of gene editing technologies like CRISPR to genetically modify human beings, but clearly there’s a long way to go and much more to do on this front. By the way, you may find this new

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Juan Carlos Izpisua Belmonte Cell Paper on Gene Editing for Mitochondrial Disease

April 23, 2015 / Professor Paul Knoepfler, Ph.D. / 2 Comments

The Juan Carlos Izpisua Belmonte group published a Cell paper today on using gene editing to reverse mutations associated with human mitochondrial disease. The paper is Reddy, et al. and is entitled, “Selective Elimination of Mitochondrial Mutations in the Germline by Genome Editing”. The authors report success using TALEN-based gene editing or mitochondrial-direct restriction enzyme (mito-ApaLI)

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Jennifer Doudna Interview on CRISPR, Human Gene Editing

April 14, 2015 / Professor Paul Knoepfler, Ph.D.

I’m doing a series of interviews with leaders in the field on human germline modification with the first interview in this series with George Church and today’s second in this series is a conversation I had with Dr. Jennifer Doudna, a pioneer in CRISPR-Cas9 technology. Doudna is a Professor in MCB and Chemistry as well

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5 new cool papers on CRISPR Cas9 gene editing

April 8, 2015 / Professor Paul Knoepfler, Ph.D.

CRISPR Cas9 is a relatively new, powerful approach to gene editing and genetic modification more generally. In the relatively short window of time in which this technology has been widely available for gene editing applications it has already evolved rapidly to become more powerful. Here are some new papers of interest on this technology. With

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Intensifying dialogue on human germline gene editing

March 19, 2015 / Professor Paul Knoepfler, Ph.D. / 1 Comment

The field recently saw Lanphier, et al. in Nature calling for a moratorium on human germilne CRISPR genetic modification. A number of additional stakeholders are expected to be weighing in soon on the issue of human germline gene editing. For example, a Science paper from others in the gene editing community is anticipated soon and may well have somewhat different perspectives. I’ve been

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Readers across the globe favor moratorium on gene editing of human germ cells in poll

March 18, 2015 / Professor Paul Knoepfler, Ph.D.

In a still ongoing on-line poll, readers of this blog show a pattern of consistently favoring a moratorium on genetic modification of human germ cells. With more than 150 votes cast, the top two answers are ‘strongly favor’ and ‘favor’ a moratorium on human germline genetic modification. Only 15% strongly opposed a moratorium. Overall those

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