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Weekly reads: brain aging, perinatal stem cell clinics, $1M lab meat fine bill

February 18, 2024 February 17, 2024 / By Professor Paul Knoepfler, Ph.D. / 1 Comment

What happens during brain aging and how can we tell if dementia is coming? Are there particular early hallmarks? There are an increasing number of medical tests for predicting or detecting dementia. Alzheimer’s disease can often be detected early. But what do patients or their doctors do with such information? Until recently there weren’t any …

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20 stem cell & regenerative medicine predictions for 2024

January 3, 2024 January 10, 2024 / By Professor Paul Knoepfler, Ph.D. / 4 Comments

Each year I make predictions for the stem cell and regenerative medicine field for the following year. Today’s prediction post is focused on what to expect in 2024. You can also see my stem cell predictions for 2023 and my grades on how I did. I also have made a video version of these predictions so please …

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Lessons from 4 stem cell stocks that tanked: Celularity, Athersys, Mesoblast, BrainStorm Cell

October 3, 2023 October 3, 2023 / By Professor Paul Knoepfler, Ph.D. / 11 Comments

Athersys stock, Athersys, stem cell stocks

I’ve been following 24 stem cell stocks for a few years. I haven’t invested in them or any others recently, but rather just find them interesting. How are these doing in 2023? Mostly not great. In some cases, it is downright disastrous. Let’s take a quick look at four stocks very much in the news over …

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Weekly reads: stem cells for MS, Kimera Labs IND, FDA lawsuit

October 1, 2023 September 30, 2023 / By Professor Paul Knoepfler, Ph.D. / 10 Comments

There has been a steady stream of encouraging data on stem cells for MS. Particularly for certain kinds of MS. A new study adds to this upbeat direction. Good news on stem cells for MS Haematopoietic stem cell transplantation for treatment of relapsing-remitting multiple sclerosis in Sweden: an observational cohort study, Journal of Neurology, Neurosurgery, …

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Hoping for approval, Mesoblast says FDA wants new remestemcel-L trial

August 3, 2023 August 3, 2023 / By Professor Paul Knoepfler, Ph.D. / 1 Comment

Australian biotech Mesoblast has had a rollercoaster ride working toward FDA approval of its mesenchymal cell therapy product remestemcel-L. They are seeking approval for use in patients with graft-versus-host disease (GvHD). More specifically, it is intended for pediatric patients with steroid-refractory acute graft versus host disease, or SR-aGVHD. This is a serious condition and new treatment …

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Heart stem cells trial mostly disappoints but is oversold

March 2, 2023 March 13, 2023 / By Professor Paul Knoepfler, Ph.D. / 6 Comments

Are there endogenous adult heart stem cells that are useful in cardiac disease or can stem cell infusions help ailing hearts? As to the first question, the adult heart does not appear to have meaningful numbers of true stem cells. Further, testing the idea of infusions of stem cells for heart disease has so far been giving …

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Fact-checking stem cell stroke therapy: hope but not there yet

December 13, 2022 December 13, 2022 / By Professor Paul Knoepfler, Ph.D. / 9 Comments

Stem cell stroke therapy research has generated buzz over the years. The goal of today’s post is to fact-check claims about supposed stem cell stroke therapies and educate readers on where clinical research stands. There is some real hope here in the long run, but things have been greatly exaggerated at times. Some clinics are …

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Digging into the multiple ways to get stem cells

October 13, 2022 October 13, 2022 / By Professor Paul Knoepfler, Ph.D. / Leave a Comment

I get great questions from readers of The Niche including, “Are there multiple ways to get stem cells?” The answer is “yes.” Why is this important? The different sources of stem cells can impact both their use in basic research and their potential clinically. My goal in today’s post is to give an overview of …

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Weekly reads: stem cell activator, sleep & stem cells, clonal hematopoiesis

September 25, 2022 September 24, 2022 / By Professor Paul Knoepfler, Ph.D. / Leave a Comment

stem cells macrophages, stem cell activator

When people find out that I’m a stem cell researcher, a common question is whether there’s something they can take that is a stem cell activator. I’ve written before about whether there are stem cell boosts that one can do to try to be healthier. Sleep, stem cell activator and clonality Mostly when I bring …

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Weekly stem cell reads: space, plagiarism, HIV, diabetes, more

July 31, 2022 July 30, 2022 / By Professor Paul Knoepfler, Ph.D. / Leave a Comment

I took a cross-country road trip earlier this month that was pretty amazing and barely thought about stem cell research for the first time in years. We did run across one stem cell clinic in Florida by accident. I’ll write about that trip soon, but first we have our weekly reads including some very cool …

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