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Weekly reads: Marc Tessier-Lavigne probe, Neuralink on the brain, Ras unchained

December 4, 2022 / Professor Paul Knoepfler, Ph.D. / Leave a Comment

We’ll start with a story related to possible research misconduct, Stanford’s President Marc Tessier-Lavigne, and Science Magazine. In some ways the news on Science itself could be the bigger long-term story. Marc Tessier-Lavigne pub investigation, Science oops moment Here’s some of the coverage: Stanford investigates potential misconduct in president’s research, Science. Multiple publications of Marc Tessier-Lavigne […]

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Weekly stem cell reads: bat stem cells, brainier organoids, more

October 2, 2022 / Professor Paul Knoepfler, Ph.D. / 1 Comment

I’m working to send out a big grant on Tuesday so I’m busier than ever but a few stem cell and regenerative medicine stories caught my eye. I can’t write grants 24/7 without a few breaks although sometimes it feels like that’s what I’m doing. Bat stem cell derivation Pluripotent bat stem cells as a

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How brain organoids are transforming research

August 2, 2022 / Professor Paul Knoepfler, Ph.D. / Leave a Comment

Organoids including brain organoids are an exciting, relatively new area of research. This technology is having a powerful impact on biomedical science, which is the focus of today’s post. What’s in this post Definition of organoids | Brain organoids | Challenges for mini-brains | Cutting edge cerebral organoids | References Definition of organoids and brain organoids

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Weekly reads: $1B Saudi anti-aging push, OCT4 necklace, cancer trial wows, coffee brain

June 12, 2022 / Professor Paul Knoepfler, Ph.D. / 1 Comment

I recently wrote about stem cell-related ideas for anti-aging and even cheating death, but there are of course other approaches including drugs like metformin. A new article outlines a massive research funding plan to tackle aging. Let’s start with that. Recommend reads including anti-aging Saudi Arabia plans to spend $1 billion a year discovering treatments to

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Weekly reads: our new brain tumor paper, levitation, dear doctor, Japan, more

May 22, 2022 / Professor Paul Knoepfler, Ph.D. / Leave a Comment

There’s nothing quite like getting a new paper out as a scientist running a research lab so this week we can celebrate our new pediatric brain tumor study. I’ll start the weekly reads with that paper. Of course, getting new grants is amazing too but there’s more of a feel of completion after a paper

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Weekly reads: neural stem cells, CRISPR brain, Vertex, cytoplasm surprise

May 15, 2022 / Professor Paul Knoepfler, Ph.D. / Leave a Comment

Some people consider the brain to be equivalent to a living computer and in that sense it’s too bad that computers don’t have the equal of neural stem cells to help them fix themselves. Is the internet one big neural network-like web? There was a quake in the stem cell internet as CIRM’s main website

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Nature paper claims young CSF fights brain aging in mice

May 11, 2022 / Professor Paul Knoepfler, Ph.D. / Leave a Comment

A new Nature paper argues that young CSF fights brain aging. Young CSF vs. young blood CSF is the cerebrospinal fluid that surrounds the brain, including those of young mice. The claim is that when young CSF is injected into the brain/CNS cavity of old mice, it makes the aged brains seem younger. And function

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Weekly reads: New FDA guidance, brains, MSCs, senescence

October 10, 2021 / Professor Paul Knoepfler, Ph.D. / 1 Comment

This week marked the release of new draft FDA guidance on cell and gene therapies. Is the FDA kind of like the guidance counselor at school or more like the principal? It probably depends on many factors. I also find it funny how pretty much everyone in academia and biotech industry works to be compliant

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A look at “eyes on the brain organoids” Cell Stem Cell paper

August 17, 2021 / Professor Paul Knoepfler, Ph.D. / 2 Comments

Sometimes a paper really catches your eye like a new Cell Stem Cell pub reporting eye-like structures grown on brain organoids. The paper is Human brain organoids assemble functionally integrated bilateral optic vesicles. Let’s take a quick look at this paper, its context, and the potential big-picture implications. Brain organoids with “eyes”? At first glance,

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Regenerative reads: brain organoids, Clinicaltrials.gov change

February 28, 2021 / Professor Paul Knoepfler, Ph.D. / 1 Comment

Sometimes change takes a very long time, but with brain organoids or advocating for better information for patients at Clinicaltrials.gov, after waiting you can see some interesting developments. These are two of the regenerative medicine stories of the week, along with some striking research papers. Clinicaltrials.gov Some of us have been advocating for improvements at

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