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Live Blogging #GeneEditSummit Day 2 Post #1: Governance of human gene editing

December 2, 2015 / Professor Paul Knoepfler, Ph.D.

Now we have an interesting panel starting on questions of governance on human gene editing. This will focus on institutional and national levels of governance. Pilar N. Ossorio, University of Wisconsin, Madison, and Morgridge Institute for Research, is introducing the panel. Key question: how should emerging technologies being governed? Jonathan Kimmelman, from McGill, was the first […]

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Live Blogging #GeneEditSummit Day 1 Post #3: human germline modification

December 1, 2015 / Professor Paul Knoepfler, Ph.D. / 2 Comments

Robin-Lovell-Badge-Peter-Braude-George-Church

The post-lunch session is “Applications of Gene Editing Technology: Human Germline Modification”. Prior to hearing it I’m curious how cautious or gung-ho the speakers will be, or if their gestalt will be one of balance in the middle somewhere. Robin Lovell-Badge, The Francis Crick Institute, was the moderator of this session. He said, “We’d be

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Nita Farahany Interview on Human Germline Modification: Defining A Road Forward

July 28, 2015 / Professor Paul Knoepfler, Ph.D. / 1 Comment

The topic of heritable human genetic modification has been heating up recently. Prominent scientists, ethicists, and legal scholars have being weighing in, and there is a range of attitudes. Some favor a complete, moratorium including even lab work, while on the other end of the spectrum there are those who have a more liberal perspective. Many

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Unapologetic He Jiankui eager for more human germline gene editing with help from tech bros

November 5, 2024 / Professor Paul Knoepfler, Ph.D. / 2 Comments

For a few years, biophysicist He Jiankui might have been one of the most recognizable scientists on the planet. He made three “CRISPR babies” or gene edited people. However, his gene editing went badly and as best as we can tell his efforts did not result in precision edits. It’s unclear if he had institutional

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Weekly reads: big CRISPR mtg, Mesoblast good news, Neuralink spiked

March 12, 2023 / Professor Paul Knoepfler, Ph.D. / 1 Comment

Where do things stand with potential applications of CRISPR and other gene editing technologies in patients? Overall, things are looking very positive. CRISPR human trials This week the third big international human genome editing meeting took place in London. The summit addressed numerous potential clinical applications. It was good to see the agenda included quite

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Grading my 20 stem cell predictions for 2020

December 30, 2020 / Professor Paul Knoepfler, Ph.D. / 1 Comment

Knoepfler-The-Niche-stem-cell-blog-predictions-2020

Each year I metaphorically try to look into a crystal ball for stem cell predictions for the coming year and I did so for 2020, but the COVID-19 pandemic threw a monkey wrench into my predictions. It actually kind of blew some up. It also raised some interesting questions and dilemmas. For instance, do many

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New human genome editing (HHGE) academy report: solid, but key gaps

September 8, 2020 / Professor Paul Knoepfler, Ph.D. / Leave a Comment

The-International-Commission-on-the-Clinical-Use-of-Human-Germline-Genome-Editing-HHGE

Something called, “The International Commission on the Clinical Use of Human Germline Genome Editing” has issued a new report on heritable human genome editing (HHGE). The Commission was convened by the U.S. National Academy of Medicine, the U.S. National Academy of Sciences, and the U.K.’s Royal Society. This post is my initial take on the summary of

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CAR-T cells review: cancer & a critical look at possible uses in aging & COVID-19

September 3, 2020 / Suhas Sakamuri / 2 Comments

Introduction to CAR-T cells CAR-T cells are an exciting cutting-edge technology that has been garnering great interest including in the stem cell field. Potential therapeutic uses of CAR-T, which stands for Chimeric Antigen Receptor T-Cells (CAR-T), are being studied in clinical trials as immunotherapies to potentially fight cancer as well as many other diseases by

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20/20 vision? The Niche’s 20 stem cell & regenerative medicine predictions for 2020

January 2, 2020 / Professor Paul Knoepfler, Ph.D. / 4 Comments

Every year in December and early January I do a post predicting some key events for the stem cell and regenerative medicine field for the upcoming year and today’s post contains my predictions for 2020. You can see my past 2019 predictions along with my grades for them here. I gave myself a B+ for

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Surprising reason why human cloning may produce someone else

July 5, 2018 / Professor Paul Knoepfler, Ph.D. / 4 Comments

“If I’m going to the trouble of cloning myself, I want the clone to be a copy of me!” I’m imagining what someone might say if they were told that their expensive and ethically dubious personal cloning efforts produced a clone that was somebody else instead of them. Even if the clone was very similar

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