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Monkey human embryo chimera Cell paper: exciting, ethically complex direction

April 15, 2021 / Professor Paul Knoepfler, Ph.D. / 5 Comments

A new Cell paper from an international team led by Juan Carlos Izpisua Belmonte pushes human embryo chimera embryo research further than ever before. It is both exciting work and raises many complex bioethics questions at the same time. What is a human embryo chimera? By way of background, chimeric human embryos contain a mixture […]

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Weekly reads: embryo pubs stir things up, organoids crying, & more

March 21, 2021 / Professor Paul Knoepfler, Ph.D. / 1 Comment

This was an unusual week in that three papers in a sense collided together related to embryo production and growth, raising new research possibilities but also serious ethical questions. New research: what is an embryo & what is not? The first two Nature papers reported generating the most realistic models of human embryos from scratch

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New lab-grown blastoids are strikingly similar to human embryos

March 17, 2021 / Ricki Lewis / 2 Comments

A new word has been added to the lexicon of human stem cell research – blastoids, aka “blastocyst-like structures.” Unlike the familiar three-layered embryo that emerges during the third week of prenatal development, the earlier blastocyst resembles a fluid-filled soccer ball, with a smear of cells on the interior face destined to develop into the

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Do human Very Small Embryonic-Like Stem Cells (VSEL) exist as a normal population of actual stem cells?

November 27, 2012 / Professor Paul Knoepfler, Ph.D. / 3 Comments

Supposedly there is a type of normal adult stem cell that intrinsically possesses many of the same properties as embryonic stem cells (ESCs). No reprogramming needed. No blastocysts needed. These reportedly amazing cells, called Very Small Embryonic-Like Stem Cells (VSELs), can in theory be isolated from umbilical cord blood (UCB) or even bone marrow. Yet

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Weekly reads: hit pause on human life, CIRM pause, 23andMe data, blast from the past

October 13, 2024 / Professor Paul Knoepfler, Ph.D. / 20 Comments

Remember cryonics, the idea that you could hit pause on human life? This relies on the super-cold power of liquid nitrogen or some other ultra-freezing method. Apparently cryonics is still a thing and there are people with even just their heads frozen. A new story claims a different way to hit the pause button on

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20 stem cell & regenerative medicine predictions for 2024

January 3, 2024 / Professor Paul Knoepfler, Ph.D. / 4 Comments

Each year I make predictions for the stem cell and regenerative medicine field for the following year. Today’s prediction post is focused on what to expect in 2024. You can also see my stem cell predictions for 2023 and my grades on how I did. I also have made a video version of these predictions so please

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2023 stem cell predictions grades reflect wild year for regenerative medicine

December 27, 2023 / Professor Paul Knoepfler, Ph.D. / 1 Comment

Every year I make stem cell and regenerative medicine predictions. Looking at my predictions for 2023, they reflect a wild year but in many ways a good one overall. Below I have graded my 2023 predictions. Overall, my crystal ball gave solid results. Some of the predictions have been condensed to keep things concise, but you

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Weekly reads: stem cell-assisted IVF, Takeda MSC trial, reporters getting stem cells

October 22, 2023 / Professor Paul Knoepfler, Ph.D. / 1 Comment

stem cell-assisted IVF, Dina Radenkovic, Gameto

There’s been much discussion about issues related to stem cells in the reproductive space such as human embryo models and differentiating stem cells into gametes, but there’s also interest in stem cell-assisted IVF. In this kind of method, stem cells are employed to make tissue cells such as ovarian stromal cells to support production of

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