Search Results for: germline crispr

Why CRISPR baby production (if it happened) was unethical & dangerous

Jiankui-He-who-claims-CRISPR-baby-production

Reports are out that a scientist in China has been working to make a CRISPR baby for some time and supposedly has made twin genetically modified babies. I see this work as unethical and dangerous. Just a couple years ago when I published my book GMO Sapiens on potential use of CRISPR in a heritable manner …

Why CRISPR baby production (if it happened) was unethical & dangerous Read More »

The Hope of CRISPRcon: Year 2, Guest Post by Anna Everette

Anna-Everette

By Anna Everette The title of this article is partially borrowed from a fascinating Lightning Presentation delivered by John Doench of Broad Institute at CRISPRcon this year. In his talk, Mr. Doench pointed out how we’ve been looking up to this promising technology for a while now, hoping it will deliver the anticipated results (see …

The Hope of CRISPRcon: Year 2, Guest Post by Anna Everette Read More »

Countering that Pro-Heritable Human CRISPR WSJ Piece

human-embryo-modification

It’s germline, heritable human CRISPR time, right? Wrong. But the particularly enthusiastic supporters of heritable human CRISPR often cite hypothetical benefits in glowing terms, but either don’t mention risks or strongly downplay them. These fans also tend to leave alternative, proven and safe technologies such as preimplantation genetic diagnosis (PGD) out of the discussion or …

Countering that Pro-Heritable Human CRISPR WSJ Piece Read More »

Why Mitalipov’s ‘magic’ room for human embryo CRISPR may give us pause

Shoukhrat-Mitalipov

The debate over whether the main conclusions of the Nature paper on human embryo CRISPR led by Shoukhrat Mitalipov’s lab at Oregon Health Sciences University (OHSU) are correct remains unresolved. Note that Nature just added an editorial alert just above the references section to their paper: “Updated online 02 October 2017. Editorial Note: Readers are alerted that some …

Why Mitalipov’s ‘magic’ room for human embryo CRISPR may give us pause Read More »

Mulling over that Mitalipov human embryo CRISPR pub, still many questions

human-embryo-modification

What really happened at the DNA level in the experiments in that high-profile CRISPR of human embryos paper from a team led by Shoukhrat Mitalipov at OHSU? Is the team right that they successfully conducted CRISPR of human embryos to correct a mutant gene, as they reported in their Ma, et al. Nature paper? Or is the Egli, …

Mulling over that Mitalipov human embryo CRISPR pub, still many questions Read More »

4 key reasons Mitalipov paper doesn’t herald safe CRISPR human genetic modification

CRISPR-dart-board

We can be confident that human genetic modification via CRISPR’ing of embryos soon will be safe and effective after that new exciting Mitalipov team paper, right? Wrong. The reality is far more complicated and interesting on the tech side. In a nutshell, I see the paper as a significant scientific, but not necessarily medical advance. …

4 key reasons Mitalipov paper doesn’t herald safe CRISPR human genetic modification Read More »

Review of Mitalipov paper CRISPR’ing human embryos: transformative work on the edge

Human-embryo-CRISPR

In the same way perhaps that some excited relatives or parents-to-be both gush and worry about a baby before it is even born, our field has been transfixed for a week by the Mitalipov paper on CRISPR’ing human embryos even though the paper just now came out. Now that the paper is out, we can …

Review of Mitalipov paper CRISPR’ing human embryos: transformative work on the edge Read More »

Big 5 questions anticipating Mitalipov human embryo CRISPR paper

human-embryo-modification

The human embryo CRISPR paper with Shoukhrat Mitalipov as senior author is coming soon. It will reportedly be focused on the use of CRISPR to genetically modify viable human embryos for reversal of a disease-associated mutation. While strangely press already broke early on this paper last week, as much as a week before the paper …

Big 5 questions anticipating Mitalipov human embryo CRISPR paper Read More »

CRISPR, human genetic modification, & a needed course correction

coverGMO-e1498086048321

Are designer babies made using CRISPR or other genetic modification technologies closer to reality today? If so, what exactly should we do about it? Researchers can use CRISPR to genetically modify just about any organism or its cells, but targeting humans is the subject of the most intense discussion including using CRISPR in the human germline …

CRISPR, human genetic modification, & a needed course correction Read More »

Human embryo CRISPR pub includes plagiarism: the victim’s unique account

Plagiarism

Cut, modify, paste… It’s kind of a CRISPR mantra for those of us using gene editing in the lab. But it’s supposed to be happening just on DNA, right? Now it appears that someone on a team of human embryo CRISPR researchers possibly got carried away with the cutting-modifying-pasting mindset to take it beyond DNA to also do …

Human embryo CRISPR pub includes plagiarism: the victim’s unique account Read More »