Search Results for: germline crispr

4 key reasons Mitalipov paper doesn’t herald safe CRISPR human genetic modification

February 1, 2021 / By / 2 Comments
CRISPR-dart-board

We can be confident that human genetic modification via CRISPR’ing of embryos soon will be safe and effective after that new exciting Mitalipov team paper, right? Wrong. The reality is far more complicated and interesting on the tech side. In a nutshell, I see the paper as a significant scientific, but not necessarily medical advance. …

4 key reasons Mitalipov paper doesn’t herald safe CRISPR human genetic modification Read More »

Review of Mitalipov paper CRISPR’ing human embryos: transformative work on the edge

February 1, 2021 / By / 3 Comments
Human-embryo-CRISPR

In the same way perhaps that some excited relatives or parents-to-be both gush and worry about a baby before it is even born, our field has been transfixed for a week by the Mitalipov paper on CRISPR’ing human embryos even though the paper just now came out. Now that the paper is out, we can …

Review of Mitalipov paper CRISPR’ing human embryos: transformative work on the edge Read More »

Big 5 questions anticipating Mitalipov human embryo CRISPR paper

February 1, 2021 / By
human-embryo-modification

The human embryo CRISPR paper with Shoukhrat Mitalipov as senior author is coming soon. It will reportedly be focused on the use of CRISPR to genetically modify viable human embryos for reversal of a disease-associated mutation. While strangely press already broke early on this paper last week, as much as a week before the paper …

Big 5 questions anticipating Mitalipov human embryo CRISPR paper Read More »

CRISPR, human genetic modification, & a needed course correction

February 1, 2021 / By / 9 Comments
coverGMO-e1498086048321

Are designer babies made using CRISPR or other genetic modification technologies closer to reality today? If so, what exactly should we do about it? Researchers can use CRISPR to genetically modify just about any organism or its cells, but targeting humans is the subject of the most intense discussion including using CRISPR in the human germline …

CRISPR, human genetic modification, & a needed course correction Read More »

Human embryo CRISPR pub includes plagiarism: the victim’s unique account

February 1, 2021 / By / 5 Comments
Plagiarism

Cut, modify, paste… It’s kind of a CRISPR mantra for those of us using gene editing in the lab. But it’s supposed to be happening just on DNA, right? Now it appears that someone on a team of human embryo CRISPR researchers possibly got carried away with the cutting-modifying-pasting mindset to take it beyond DNA to also do …

Human embryo CRISPR pub includes plagiarism: the victim’s unique account Read More »

Paper on 1st use of CRISPR in normal human embryos: problems remain

February 1, 2021 / By / 1 Comment
CRISPR-human-embryo-Tang-et-al

The first report of the use of CRISPR gene editing in normal human embryos was published today as a short paper from a team in China. There have been rumors for over a year that more CRISPR human embryo papers were coming including some using normal embryos. Here’s one and we can now expect more even …

Paper on 1st use of CRISPR in normal human embryos: problems remain Read More »

Interview with Fredrik Lanner who is CRISPR’ing healthy human embryos

February 1, 2021 / By / 2 Comments
ssistant-Professor-Fredrik-Lanner--e1474733944943

In the past year there has been a great deal of attention given to the potential use of CRISPR-Cas9 for gene editing in human embryos. An important recent development, described in a new NPR article by Rob Stein, is the use of CRISPR-Cas9 in healthy human embryos for developmental biology research by assistant professor Fredrik …

Interview with Fredrik Lanner who is CRISPR’ing healthy human embryos Read More »

Where are all the new CRISPR human embryo papers?

February 1, 2021 / By / 4 Comments
embryo-human

Last year I heard from several sources that there somewhere between 3-5 unpublished manuscripts reporting the use of CRISPR gene targeting in human embryos being shopped around at various journals in addition to the one that had been published. Since that time we’ve seen a grand total of one additional paper reporting on CRISPR of human …

Where are all the new CRISPR human embryo papers? Read More »

First anti-CRISPR political campaign is born in Europe

February 1, 2021 / By / 2 Comments
Stop-Baby-GM

Campaigns are underway in several European countries against the possible use of genetic modification in humans to make designer babies and one has a distinctly anti-CRISPR tone. For example, in France a group is pushing an anti-GM baby campaign and the same kind of thing is going on in Switzerland, which I blogged about recently. In …

First anti-CRISPR political campaign is born in Europe Read More »

TGIF Science: funding, CRISPR v. NgAgo, secrets, Zika, & more

February 1, 2021 / By / 2 Comments
TGIF-science-dart-board

Some stuff on my mind for our TGIF Science this week. Research Funding Ups: NIH. Is it my imagination or is NIH funding slightly improving? This is the overall vibe I’m hearing from the trenches. Research Funding Ups and Downs: CIRM.  CIRM funded some basic research to the tune of a total of $4 million, …

TGIF Science: funding, CRISPR v. NgAgo, secrets, Zika, & more Read More »