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Quick journal club on IPSC anti-aging paper: cool, but outstanding questions

December 15, 2016 February 1, 2021 / By Professor Paul Knoepfler, Ph.D. / 6 Comments

A new Cell paper from Juan Carlos Izpisua Berlmonte’s group has made headlines about anti-aging across the globe because it suggests that the four core induced pluripotent stem cell (IPSC) factors use by Shinya Yamanaka to make IPSC can reverse aging. I’ve pasted the graphical abstract from the paper below and done a quick journal club style …

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Some cool recent stem cell papers: recommended reading

July 17, 2014 February 1, 2021 / By Professor Paul Knoepfler, Ph.D. / 3 Comments

What have been some recent stem cell and/or regenerative medicine papers that are worth some extra thought and reading? There have been some cool ones. Note, for fun you can fast forward ahead to 2020 to see some of the recommended reads there. There was of course the very important Mitalipov group paper comparing NT …

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Nominees for Stem Cell Person of the Year 2013: scientists, advocates, physicians, and the Pope

October 1, 2013 December 22, 2023 / By Professor Paul Knoepfler, Ph.D. / 3 Comments

Nominations for Stem Cell Person of the Year 2013 closed last night and I ended up with a remarkable list of 30 nominees. I have included a few sentences about each one below, often taking verbiage directly from the nominator. The online voting on these nominees will start soon. The top vote getters will move …

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Stem cell journal club: dishing on Nature paper on making iPS cells inside mice

September 11, 2013 February 1, 2021 / By Professor Paul Knoepfler, Ph.D. / 13 Comments

What if you could reprogram cells inside of an organism to a different fate and, for instance, make IPS cells? We can, right? But when most of us think about making induced pluripotent stem (iPS) cells, we imagine it all happening in a little plastic dish in our labs or in our colleague’s labs, not …

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Regenerative Medicine outlook: Five simple ways to protect your stem cells and your health

August 3, 2010 February 1, 2021 / By Professor Paul Knoepfler, Ph.D.

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Regenerative medicine is very exciting. But what’s even better than regenerative medicine? Preventative medicine. If one can prevent a problem for occurring in the first place, it is far better than trying to treat it after the fact. Of course in many cases we do not know the causes of diseases so it is difficult …

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Weekly reads: stem cells for MS, good news x2, extending dog years, Neuralink updates

December 3, 2023 December 2, 2023 / By Professor Paul Knoepfler, Ph.D. / 2 Comments

For about as long as I’ve been writing The Niche, people have been asking about stem cells for MS. There’s a huge need for new therapies. While a chemo-based approach with autologous hematopoietic stem cell transplantation (HSCT) looks to work for certain cases of multiple sclerosis (although not yet approved in the US), other cell …

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The role of belief in hard science: the VSEL case

April 4, 2023 April 4, 2023 / By Professor Paul Knoepfler, Ph.D. / 5 Comments

As we think about how much of a role belief should play in the hard sciences such as cell biology, a supposed cell type called VSEL or very-small embryonic stem cell-like cells comes to mind. For these guys it seems to me that the ratio of data to belief isn’t great. VSELs have nine lives. I …

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Weekly reads: oocytes from males, David Sinclair longevity inc, diabetes, He Jiankui

March 19, 2023 March 18, 2023 / By Professor Paul Knoepfler, Ph.D. / Leave a Comment

A team led by Harvard professor David Sinclair had a recent Cell paper on reprogramming to fight aging that I reviewed here on The Niche. I thought the paper was exciting and important. Note that in vivo reprogramming was first done more than a decade ago. Sinclair did have a novel fast-forward aging method and overall …

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Weekly reads: stem cell niche & AI stumble on health

February 12, 2023 February 11, 2023 / By Professor Paul Knoepfler, Ph.D. / 2 Comments

What is a stem cell niche? It’s the home of stem cells. The stem cell niche is a fascinating environment. It has many constituents that impact stem cell behavior and even eventual stem cell transplant functions. In today’s weekly reads, we’ll start with the niche as there have been several interesting papers on this topic. The …

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Paper sparks renewed interest in transdifferentiation & clinical potential

September 8, 2022 September 8, 2022 / By Professor Paul Knoepfler, Ph.D. / 1 Comment

There was a time when I thought transdifferentiation based approaches might quickly move into clinical trials. Then things kind of cooled off. We didn’t see many papers reporting methods to transdifferentiate cells. I still think that this technology, sometimes called direct reprogramming, has major potential. A new paper on making human brain cells this way got …

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