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Small positive step for BlueRock Therapeutics Stem Cell Therapy for Parkinson’s

August 28, 2023 / Professor Paul Knoepfler, Ph.D. / 4 Comments

BlueRock Therapeutics, Parkinson's disease, brain imaging

Several groups including Viviane Tabar who is a founding scientist at BlueRock Therapeutics are moving forward on potential cell therapies for Parkinson’s Disease. BlueRock just released some new data that’s worth a look. Check out the new BlueRock poster. In today’s post, I briefly discuss the new data. I also go into the larger context […]

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Weekly reads: embryonic stem cells, Parkinson’s, Alzheimer’s

August 13, 2023 / Professor Paul Knoepfler, Ph.D. / 6 Comments

Early during my postdoc I was primarily interested in the role of Myc genes both in cancer and in stem cells, work that later included embryonic stem cells. These cells are often called ES cells. At first I first started studying N-Myc in neural stem cells using a conditional knockout approach. However, soon after I was

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Weekly reads: UC Davis Medical School diversity, CRISPR, Parkinson’s

March 26, 2023 / Professor Paul Knoepfler, Ph.D. / 2 Comments

It’s been almost seventeen years that I’ve been a professor here at UC Davis Medical School. It feels like home. I enjoy teaching our first-year medical students each year. Some end up doing research in my lab. Our school recently got a nice write-up over at STAT News by Usha Lee McFarling on the diversity

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Weekly reads: CRISPR’d marsupial, outpatient recovery post stem cell transplants, Parkinson’s, pubs

July 25, 2021 / Professor Paul Knoepfler, Ph.D. / 3 Comments

This edition of The Niche weekly reads has a bit more good news than usual including on stem cell transplants. It’s nice to see positive developments like some recipients of hematopoietic stem cell transplants being able to stay at home afterwards. Also, a reminder. You have until July 31 to enter our stem cell video

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Stem cell news & pubs: Parkinson’s, Freezing, COVID, & More

May 31, 2020 / Professor Paul Knoepfler, Ph.D. / 7 Comments

Moll-et-al.-effect-of-freezing-on-stem-cells-stem-cell-news-FI

I find following both stem cell news and the stream of interesting publications to be kind of fun and thought-provoking. This past week or two has been very busy. Here is a news summary and list of notable pubs. Stem Cell News on Parkinson’s Disease There were a number of interesting developments on the Parkinson’s

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IPS cell field update: easy culture, Parkinson’s, scarring, immune cells, & mutations

January 12, 2020 / Professor Paul Knoepfler, Ph.D. / 1 Comment

Fibrosis-model-IPS-cells-Fig-1b-Vijayaraj-et-al-Cell-Reports-2019

Where do things stand today in 2020 with IPS cell research? It’s been 14 years since they were first reported, but they continue to make news. Back in 2006 I was wrapping up my postdoc with Bob Eisenman at The Hutch in Seattle, largely studying Myc, when Shinya Yamanaka published his first induced pluripotent stem

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Hope on Parkinson’s front: Japan IPSC trial 1st patient

November 18, 2018 / Professor Paul Knoepfler, Ph.D. / 2 Comments

Fig-3i-Kikuchi-et-al.-Nature-2017-IPS-cell-Parkinsons-

In Parkinson’s Disease patients develop neurological dysfunction as they lose a special kind of brain cell called dopaminergic (or dopamine) neurons. While a number of different approaches to this disease have been studied for decades, nothing has proven particularly successful in slowing its progression. As a result there has been a big need for novel thinking

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On the threshold of cell therapy for Parkinson’s disease

November 13, 2017 / Professor Paul Knoepfler, Ph.D. / 7 Comments

Dopamine-neurons-derived-from-a-Parkinsons-disease-patients-iPSCs-Tyrosine-hydroxylase-1

By Jeanne Loring There are ten million people in the world who have Parkinson’s disease. 125,000 of these are living in California. People with the disease often have to step away from their jobs because the main symptoms – tremor or freezing up of muscles – make it difficult to get through a whole day

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How risky are stem cell trials for Parkinson’s beginning in China?

June 1, 2017 / Professor Paul Knoepfler, Ph.D. / 16 Comments

New human clinical trials using derivatives of pluripotent stem cells in China for Parkinson’s Disease (PD) have raised expectations and some eyebrows. PD is a neurodegenerative condition, sometimes diagnosed or followed by PET scans such as the one at left, characterized by loss of dopaminergic neurons leading to severe and sometimes life-threatening symptoms. Pluripotent stem

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