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Counterpoints to Lovell-Badge & Daley’s CRISPR baby rationales

February 11, 2019 / Professor Paul Knoepfler, Ph.D. / 5 Comments

Two prominent scientists, Robin Lovell-Badge and George Daley, have been amongst the most outspoken proponents of leaving the door open to heritable human genetic modification via CRISPR. While they each have articulated their reasons in somewhat different ways at times, their core reasons arguing in favor of future heritable CRISPR appear largely the same. In

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As exosome work advances, clinics pitch unproven therapies to patients

August 26, 2018 / Professor Paul Knoepfler, Ph.D. / 29 Comments

Time to sell exosome therapies to patients? No. Some stem cell clinics and related firms are looking for new ways to make profits and toward that goal a few have latched onto the legitimate buzz around exosome research. What are exosomes? Imagine if you could bubble up a pea-sized sphere off your skin full of

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Review of Star Wars The Last Jedi: Disappointing

December 22, 2017 / Professor Paul Knoepfler, Ph.D. / 5 Comments

This post is my review of Star Wars The Last Jedi. I’m a sci-fi fan and have enjoyed the various Star Wars movies over the years so I had been looking forward to seeing the new movie, Star Wars: The Last Jedi (TLJ). Here is my review of TLJ and be forewarned that there are

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Young blood as anti-aging fountain of youth: hype or hope?

August 20, 2017 / Professor Paul Knoepfler, Ph.D. / 9 Comments

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There’s an idea floating around out there called “young blood” to use donations from young folks to infuse older people to reverse aging. I’m skeptical. Imagine an old man and a teenager sitting side by side, with blood flowing from the kid to the oldster in a stab at anti-aging. Sort of like a one-way

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A new possible environmental disaster: the gene spill

February 8, 2016 / Professor Paul Knoepfler, Ph.D.

New genetic modification technology such as CRISPR-Cas9 has opened the door to transformative biological research, but it has also set the table for some novel kinds of technological problems for which we aren’t at all prepared including one that I call the “gene spill”. The striking potential upsides to CRISPR paired with some of the

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GMO Sapiens book teaser: time to talk frankly on human genetic modification

October 23, 2015 / Professor Paul Knoepfler, Ph.D. / 2 Comments

I’ve written a new book on human genetic modification. This is my second book as the first one was Stem Cells: An Insider’s Guide, which is currently the top stem cell book on Amazon. The new book is called GMO Sapiens: The Life-Changing Science of Designer Babies. You can pre-order it here at Amazon or over here at my publisher’s

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Recommended thought-provoking books…and one I’ve been writing

September 3, 2015 / Professor Paul Knoepfler, Ph.D.

In choices of fictional books to read I gravitate toward sci-fi and fantasy. For example, in late 2014 and through the first few months of this year I read all the Game of Thrones books. The first three of those were the best and I thought definitely better than the TV show, although it’s pretty good

Kelly Hills interview: human genetic modification & bioethics

August 20, 2015 / Professor Paul Knoepfler, Ph.D. / 5 Comments

Below is a conversation with bioethics commentator Kelly Hills (who BTW has a great blog), tackling some of the key issues surrounding the potential use of CRISPR-Cas9 technology to make heritable human genetic modification. I really appreciate her clear and insightful answers to some tough questions that many are grappling with today on this topic. Part

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Fantastic organoid voyage: views from inside organoids

July 30, 2015 / Professor Paul Knoepfler, Ph.D.

The classic sci-fi movie Fantastic Voyage keeps coming to mind for me as I see and do research involving organoids. In it, the heroes travel inside of the human body in a craft, observing all kinds of awesome biology in an up close and personal kind of way on route into the brain with the goal

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More Liveyon links to exosome Awakening film include potential relative