Search Results for: elephant in the lab

Take-homes from new FDA NEJM stem cell piece including surprises

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FDA Commissioner Scott Gottlieb and CBER Director, Peter Marks, have just published a new piece on stem cells and regenerative medicine in the New England Journal of Medicine (NEJM). What are the core points here and what can we learn from reading between the lines a bit? There are some expected things and then some …

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Artificial embryo tech reported in Science: how big is this?

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Can you make an artificial embryo? Developmental biologist Magdalena Zernicka-Goetz has long been on the trail of this seemingly almost uncatchable quarry. With her team’s publication in Science today they took a big step forward on this path even if some major hurdles remain. You can see her discussion of the research in the YouTube video …

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Why I oppose de-extinction of woolly mammoths

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De-extinction is big right now and some of the extinct target creatures are big too like the woolly mammoth. “Let’s bring back these extinct creatures”, say proponents. Wouldn’t it be cool? I have to admit seeing a woolly mammoth, mastodon, or saber tooth tiger would be cool, but such efforts would not be without consequences …

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Jailbreak Cell Fate to Reprogram Stem Cells

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You can jailbreak your iPhone, but perhaps you can jailbreak a cell too to turn it into a stem cell. In his very cool talk up here at the Till & McCulloch Meeting on Stem Cells yesterday, Andras Nagy characterized the reprogramming process to make iPS cells as “jailbreaking” cell fate. Nagy described some intriguing studies done on …

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Human cloning successfully makes embryonic stem cells

For the first time ever, scientists have successfully used somatic cell nuclear transfer (SCNT) via the process of therapeutic human cloning to generate normal human embryonic stem cells (hESC). Recall that there are two kinds of human cloning: therapeutic (which is reported in the new paper discussed in this post) and reproductive, which is making …

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iPS cells are similar to cancer cells paper, part 2: unsettled reviewers

I’m a fan of iPS cells, but my lab has been concerned about the similarities between induced pluripotency and cancer formation for many years. We just now published a paper that directly addressed the similarities of cancer and iPS cell transcriptomes. These are cause for concern and need to be faced as we contemplate clinical …

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Transformative idea for peer review: reviewing & grading the reviewers

Do you feel frustrated with the current peer review system in science? I have an idea that might help and it involves the revolutionary idea of reviewer accountability. In other words, authors and grant writers in essence review their reviewers. I’ve made this all the easier for you with templates that you can simply and …

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What are the best iPS cell papers so far?

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What are the most important iPS cell papers so far? 1) Yamanaka’s first paper on mouse iPS cells. Revolutionary. Intriguing perspectives presented in day 1 of the iPS cell field. Interesting statements such as Myc is required. Also take a look at those other reprogramming factors that he tested…there’s a tremendous amount there, largely unexamined. …

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Insults 2.0: more ways scientists skewer each other

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Yesterday I put out a post as a guide for scientists to insult each other. More insults have been forthcoming from the blog readerships including some even nastier ones. Most are just downright mean, but some are sexist or racist. Sadly these comments are real. They skewer you and roast you over the coals, often …

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