What’s the difference between multipotent stem cells, totipotent stem cells, and pluripotent stem cells? The goal of today’s post is to help you learn and be clear on the differences. What’s in this article Definition of stem cells |Totipotent vs pluripotent stem cells | Pluripotent stem cells | Multipotent stem cells | The best kind of stem …
Multipotent & totipotent vs pluripotent stem cells Read More »
FDA Commissioner Scott Gottlieb and CBER Director, Peter Marks, have just published a new piece on stem cells and regenerative medicine in the New England Journal of Medicine (NEJM). What are the core points here and what can we learn from reading between the lines a bit? There are some expected things and then some …
Take-homes from new FDA NEJM stem cell piece including surprises Read More »
Can you make a synthetic embryo, also called an embryo model? Developmental biologist Magdalena Zernicka-Goetz has long been on the trail of this seemingly almost uncatchable quarry. With her team’s publication in Science today they took a big step forward on this path even if some major hurdles remain. You can see her discussion of …
Synthetic embryo or embryo model tech reported in Science: how big is this? Read More »
De-extinction is big right now and some of the extinct target creatures are big too like the woolly mammoth. “Let’s bring back these extinct creatures”, say proponents. Wouldn’t it be cool? I have to admit seeing a woolly mammoth, mastodon, or saber tooth tiger would be cool, but such efforts would not be without consequences …
You can jailbreak your iPhone, but perhaps you can jailbreak a cell too to turn it into a stem cell. In his very cool talk up here at the Till & McCulloch Meeting on Stem Cells yesterday, Andras Nagy characterized the reprogramming process to make iPS cells as “jailbreaking” cell fate. Nagy described some intriguing studies done on …
Today’s post is my no-B.S. guide to the possibility of stem cells being used to treat Multiple Sclerosis (MS). There is a great deal of buzz about using stem cells to treat or even cure multiple sclerosis. How much of this stem cell buzz is real hope and how much is hype? MS has a …
A no B.S. guide to stem cells for Multiple Sclerosis (MS) Read More »
For the first time ever, scientists have successfully used somatic cell nuclear transfer (SCNT) via the process of therapeutic human cloning to generate normal human embryonic stem cells (hESC). Recall that there are two kinds of human cloning: therapeutic (which is reported in the new paper discussed in this post) and reproductive, which is making …
Human cloning successfully makes embryonic stem cells Read More »
I’m a fan of iPS cells, but my lab has been concerned about the similarities between induced pluripotency and cancer formation for many years. We just now published a paper that directly addressed the similarities of cancer and iPS cell transcriptomes. These are cause for concern and need to be faced as we contemplate clinical …
iPS cells are similar to cancer cells paper, part 2: unsettled reviewers Read More »
Do you feel frustrated with the current peer review system in science? I have an idea that might help and it involves the revolutionary idea of reviewer accountability. In other words, authors and grant writers in essence review their reviewers. I’ve made this all the easier for you with templates that you can simply and …
Transformative idea for peer review: reviewing & grading the reviewers Read More »
What are the most important iPS cell papers so far? 1) Yamanaka’s first paper on mouse iPS cells. Revolutionary. Intriguing perspectives presented in day 1 of the iPS cell field. Interesting statements such as Myc is required. Also take a look at those other reprogramming factors that he tested…there’s a tremendous amount there, largely unexamined. …