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‘We don’t want to freak people out’: about that Jacob Hanna human embryo model startup

August 18, 2022 / Professor Paul Knoepfler, Ph.D. / 5 Comments

Stem cell biologist Jacob Hanna has a new startup called Renewal Bio. Its goal is to harvest cells or tissues from human embryo or fetus models for clinical use. I believe that their commercial ambitions have so far outstripped careful thought and discussion in the broader community of researchers. There are major risks here for […]

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Weekly reads: freeze-dried cloning, FDA signals, stem cell escapees

July 10, 2022 / Professor Paul Knoepfler, Ph.D. / 1 Comment

Cloning is one of those topics that both fascinates and kind of scares people, especially the idea of duplicating people. I regularly cover the topic here on The Niche because stem cell technologies are involved. Also, one form of the process sometimes called “therapeutic cloning” involves embryonic stem cells. Duplicating mammals has now long been

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When does a human embryo model become the real thing & other tough questions for a new field

May 19, 2021 / Professor Paul Knoepfler, Ph.D. / 2 Comments

A human embryo model is a laboratory-produced collection of living cells that has some key things in common with real human embryos. They are made from pluripotent stem cells, which include embryonic stem cells and induced pluripotent stem cells or iPS cells. This research is both exciting and ethically complicated, raising some difficult questions. Embryo

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Weekly roundup: CAR-T cells, exosomes, trout cloning

June 21, 2020 / Professor Paul Knoepfler, Ph.D. / Leave a Comment

Amor-et-al-3h-Nature-CAR-T-cells-aging-1

My weekly roundups of biomedical news tend to focus on stem cells, but I read more broadly so it’s not just stem cells but also CAR-T cells and a lot more this week. CAR-T cells as senolytics? A team led by Scott Lowe has a new intriguing paper in Nature on using CAR-T cells to

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Is monkey cloning a breakthrough or a bad idea?

January 24, 2018 / Professor Paul Knoepfler, Ph.D. / 10 Comments

Is monkey cloning a good idea? We’re about to find out. A new Cell paper today reports the first cloning of monkeys via somatic cell nuclear transfer (SCNT), raising many questions. The paper from a team led by Qiang Sun is entitled, “Cloning of Macaque Monkeys by Somatic Cell Nuclear Transfer.” The highlight bullet points

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Why Mitalipov’s ‘magic’ room for human embryo CRISPR may give us pause

October 3, 2017 / Professor Paul Knoepfler, Ph.D. / 7 Comments

The debate over whether the main conclusions of the Nature paper on human embryo CRISPR led by Shoukhrat Mitalipov’s lab at Oregon Health Sciences University (OHSU) are correct remains unresolved. Note that Nature just added an editorial alert just above the references section to their paper: “Updated online 02 October 2017. Editorial Note: Readers are alerted that some

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In Depth Report from April 29th Paris Human Gene Editing Meeting

May 11, 2016 / Professor Paul Knoepfler, Ph.D.

Editor’s note. Caroline Simons attended both the April 28th (see her report on that here) and 29th Paris meetings on human gene editing/genetic modification. Today, we have her in depth report on the April 29th meeting. I have posted her piece in full with only minor edits. If you are in a rush you can

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TGIF weekend reads: stem cells, GMOs, #CRISPR, cats, cloning and more

February 5, 2016 / Professor Paul Knoepfler, Ph.D.

Sounds recommended weekend reads for you to enjoy since it is Friday and almost the weekend including stem cells, CRISPR, cats, cloning, and more. Holy GMO, China wants to buy Syngenta. RetractionWatch says that Macchiarini will soon be out at Karolinska. For more on this “super surgeon” who used stem cells, see here regarding recent Vanity

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Interview with transhumanism leader Maria Konovalenko

July 6, 2015 / Professor Paul Knoepfler, Ph.D. / 21 Comments

The transhumanism movement has been garnering attention lately for a variety of views including embracing aspects of heritable human genetic modification. Earlier this year I interviewed geneticist and transhumanist, George Church. In this post I interview molecular biophysicist and transhumanist Maria Konovalenko. She is the program coordinator at the Science for Life Extension Foundation. In

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News bites & rumors on human embryo genetic modification

April 30, 2015 / Professor Paul Knoepfler, Ph.D. / 8 Comments

A lot has happened in the week since the first human embryo genetic modification paper was published by a team led by Junjiu Huang. There have been a number of new events just in the last few days. Jocelyn Kaiser over at SCIENCEINSIDER has a new piece reporting a couple important developments including that the journal

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