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National Academies panel leaves door a crack open to future human genetic modification

February 14, 2017 / Professor Paul Knoepfler, Ph.D. / 6 Comments

A National Academies panel on human genome editing chaired by Alta Charo and Richard Hynes released its report today. While it covered both somatic and germline (heritable) human genetic modification, the latter topic is far more contentious. You can see the National Academies summary of their report here. You can read the full report here. […]

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Mitochondrial Replacement Techniques, the Mexican Case

September 30, 2016 / Professor Paul Knoepfler, Ph.D.

Earlier this week New Scientist broke the news that the first baby born after Maternal Spindle Transfer (a form of mitochondrial replacement) is already five months old, and even more, he seems to be doing well. Even when John Zhang’s team has achieved a world first, I agree with Dr. Alison Murdoch in that: “The

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Hateful politics infiltrate human genome editing debate in France

June 27, 2016 / Professor Paul Knoepfler, Ph.D. / 1 Comment

By Elliot Hosman Summary. A campaign calling for a moratorium on using CRISPR in human embryos was launched by a prominent French organization fighting for narrow understandings of life and family. A recent campaign calling for a ban on “transgenic” human embryos was launched by one of France’s most prominent organizations fighting for “science”-backed “one-man-one-woman”

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In Depth Report from April 29th Paris Human Gene Editing Meeting

May 11, 2016 / Professor Paul Knoepfler, Ph.D.

Editor’s note. Caroline Simons attended both the April 28th (see her report on that here) and 29th Paris meetings on human gene editing/genetic modification. Today, we have her in depth report on the April 29th meeting. I have posted her piece in full with only minor edits. If you are in a rush you can

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George Church chat: CRISPR people, Zika, weapons

April 18, 2016 / Professor Paul Knoepfler, Ph.D. / 4 Comments

I talked last year about human genetic modification by CRISPR with George Church a year ago. Now we’ve followed up with a long chat on this topic going into much more detail and with questions on recent developments. Each question is listed numerically and then there is a back and forth on that question with George

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GOP Congress seeks ban on CRISPR of human embryos

December 16, 2015 / Professor Paul Knoepfler, Ph.D. / 3 Comments

GOP members of Congress want a ban on CRISPR of human embryos. They are moving to block genetic modification of human embryos using the new CRISPR gene editing technology. The new proposed spending bill part way through the approval process with the nugget of good news of a possible NIH spending boost after many years

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What if I could make designer babies for you? My TED talk

December 8, 2015 / Professor Paul Knoepfler, Ph.D. / 1 Comment

What’s it like to give a TED talk and could there be designer babies in your future as a parent? On Halloween I gave a TEDxVienna talk (click above) on giving consideration to the possibility that we may be headed toward a new reality in the next 15 years in which there are designer babies.

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Highlights from day 2 of #GeneEditSummit

December 3, 2015 / Professor Paul Knoepfler, Ph.D.

Day 2 of the Human Gene Editing Summit in DC (#GeneEditSummit) was quite interesting and added more depth to the meeting overall. For specific talks, see my two posts from yesterday here and here. Also see my top takeaways from Day 1. What were the top highlights of Day 2 of #GeneEditSummit? Somatic work. We

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Live Blog #GeneEditSummit Day 2 Post #2: International Governance

December 2, 2015 / Professor Paul Knoepfler, Ph.D.

How do governance issues for human genome editing work at the international level? Indira Nath, All India Institute of Medical Sciences, gives a nice overview to start the session. She raised the example of medical tourism and surrogacy in India. She argued for an international consensus on what is permissible on human gene editing. How

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Live Blogging #GeneEditSummit Day 2 Post #1: Governance of human gene editing

December 2, 2015 / Professor Paul Knoepfler, Ph.D.

Now we have an interesting panel starting on questions of governance on human gene editing. This will focus on institutional and national levels of governance. Pilar N. Ossorio, University of Wisconsin, Madison, and Morgridge Institute for Research, is introducing the panel. Key question: how should emerging technologies being governed? Jonathan Kimmelman, from McGill, was the first

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