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Keys to successful stem cell translation – Nurses, physicians and patient advocates

April 7, 2016 February 1, 2021 / By Professor Paul Knoepfler, Ph.D.

By Heather Main I recently attended the UCSD Health CIRM Alpha Stem Cell Clinics Network Symposium at the Sanford Consortium, San Diego. There was of course some great academic research presented, including conflicting views on liver stem cell compartments from Roel Nusse and David Brenner, and advances in CRISPR technologies from Matthew Porteus. However, what …

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Positive Stem Cell Developments in 2014

December 24, 2014 February 1, 2021 / By Professor Paul Knoepfler, Ph.D. / 2 Comments

A lot has happened in 2014 in the stem cell and regenerative medicine field and so much of it has been good news so let’s focus on the positive. These positive developments are often the result of many years of creative, hard work by amazing teams of researchers. Here is my top 10 list of …

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The anti-cure movement continues attacks on stem cell research, this time in Missouri

December 23, 2011 February 1, 2021 / By Professor Paul Knoepfler, Ph.D. / 1 Comment

The opponents of hope, those anti-cure crusaders, will not give up and they are active on both the state and federal levels. Today we heard from the S. Louis Beacon that “Missouri Roundtable for Life” is aiming for a 2012 ballot initiative to change the definition of human cloning in such a way that some forms …

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Weekly reads: UC Davis Medical School diversity, CRISPR, Parkinson’s

March 26, 2023 March 25, 2023 / By Professor Paul Knoepfler, Ph.D. / 2 Comments

It’s been almost seventeen years that I’ve been a professor here at UC Davis Medical School. It feels like home. I enjoy teaching our first-year medical students each year. Some end up doing research in my lab. Our school recently got a nice write-up over at STAT News by Usha Lee McFarling on the diversity …

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Weekly reads: big CRISPR mtg, Mesoblast good news, Neuralink spiked

March 12, 2023 March 11, 2023 / By Professor Paul Knoepfler, Ph.D. / 1 Comment

Where do things stand with potential applications of CRISPR and other gene editing technologies in patients? Overall, things are looking very positive. CRISPR human trials This week the third big international human genome editing meeting took place in London. The summit addressed numerous potential clinical applications. It was good to see the agenda included quite …

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Weekly reads: H3.3 on the brain, Texas bill, HSCs

January 22, 2023 January 21, 2023 / By Professor Paul Knoepfler, Ph.D. / 1 Comment

It’s always exciting when your lab has a new paper and my team just published a study knocking out the H3f3a gene in mice, which codes for histone H3.3 protein. We found that loss of this gene leads to lethality at a late stage of embryonic development. There were also indications of more specific phenotypes …

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Updates on CRISPR therapy development and clinical trials

November 22, 2022 November 22, 2022 / By Professor Paul Knoepfler, Ph.D. / Leave a Comment

When I first heard of CRISPR gene editing I was excited for my lab to try it out, but it seemed a long way from the field having even one CRISPR therapy available to treat human disease. In the Knoepfler lab, we study genetic and genomic programming in human development and disease. Gene editing seemed …

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Mesoblast MSCs Quell Peds GvHD; On Road to FDA Approval?

August 20, 2020 June 8, 2022 / By Ricki Lewis / 6 Comments

MSCs-mesenchymal-stem-cells-stromal-cells-small

Graft-versus-host disease (GVHD) is counterintuitive In the weeks and months following a transplant, a major concern is the recipient’s immune system rejecting the “foreign” biological material. But in GVHD, the opposite happens: transplanted tissue unleashes a horde of T cells that spark a cascade of inflammation, within 100 days. Typically, GVHD follows a bone marrow …

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Heads up on Hui Yang, another potential aspiring CRISPR baby researcher

January 22, 2020 February 1, 2021 / By Professor Paul Knoepfler, Ph.D. / 1 Comment

Making a CRISPR baby is a controversial idea to even propose now for many reasons, yet even after He Jiankui’s train wreck some people have seemed eager to try it including apparently a scientist whose name perhaps many readers here are not so familiar with in this context: Professor Hui Yang. ‘CRISPR baby guys’ Is …

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The Hope of CRISPRcon: Year 2, Guest Post by Anna Everette

June 12, 2018 February 1, 2021 / By Professor Paul Knoepfler, Ph.D. / 1 Comment

By Anna Everette The title of this article is partially borrowed from a fascinating Lightning Presentation delivered by John Doench of Broad Institute at CRISPRcon this year. In his talk, Mr. Doench pointed out how we’ve been looking up to this promising technology for a while now, hoping it will deliver the anticipated results (see …

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