Search Results for: embryonic stem cell

UK should freeze mitochondrial replacement as Egli paper ID’s serious problem

February 1, 2021 / By / 1 Comment
Egli-genetic-drift-paper

An important new Cell Stem Cell paper from Dieter Egli’s lab points to an inherent, serious problem with so-called 3-person IVF or mitochondrial replacement technology that warrants putting an immediate hold on all efforts to use it in humans. I have pasted the graphical abstract from the paper below. For years a few of us scientists and …

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In Depth Report from April 29th Paris Human Gene Edit Meeting

February 1, 2021 / By
Paris-Gene-Editing-Meeting

Editor’s note. Caroline Simons attended both the April 28th (see her report on that here) and 29th Paris meetings on human gene editing/genetic modification. Today, we have her in depth report on the April 29th meeting. I have posted her piece in full with only minor edits. If you are in a rush you can …

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George Church chat: CRISPR people, Zika, weapons

January 21, 2023 / By / 4 Comments
George-Church

I talked last year about human genetic modification by CRISPR with George Church a year ago. Now we’ve followed up with a long chat on this topic going into much more detail and with questions on recent developments. Each question is listed numerically and then there is a back and forth on that question with George …

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Perspectives on Pedersen Lab Human-Mouse Chimera Paper

February 1, 2021 / By / 1 Comment
human-mouse-chimera

A new Cell Stem Cell paper by Victoria L. Mascetti and Roger Pedersen on human-mouse chimera modeling is quite interesting and important. I really enjoyed this short paper, but I do have a reservation about one way that it is being interpreted. The authors show that human pluripotent stem cells (hPSC) including induced pluripotent stem cells …

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Did NHK Violate Rights of Obokata (小保方 晴子) on STAP?

February 1, 2021 / By / 13 Comments
Obokata-press-conference

The Japanese public broadcasting system, NHK, has been accused by scientist Haruko Obokata of violating her human rights. Obokata was the primary researcher involved in the STAP cell fiasco in which two ultimately retracted Nature papers contained duplicated, plagiarized, and manipulated data. She was certainly not the only researcher on those papers, but overall she …

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TGIF: recommended weekend science reads & a jar full of RNA

February 1, 2021 / By
GMO-spray-Monsanto1

TGIF recommended weekend reads including thought-provoking reading over a beer, glass of wine, or beaker…and what would RNA taste like? Two from Alexey Bersenev The future of human limb bioengineering Translating Cell Therapies: Academic versus Industry model CIRM blog: two cool recent posts Specialized Embryonic Stem Cells Yield Insights into X Chromosome Inactivation Da Mayor and …

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Mitalipov Nature pub review: IPSC & SCNT for mitochondrial disease

February 1, 2021 / By / 6 Comments
Mitalipov-IPSC-paper

In a new, thought-provoking paper today in Nature, Shoukhrat Mitalipov and a multi-institutional team report a significant advance toward potential novel ways to treat mitochondrial diseases. What are these illnesses? Mitochondrial diseases are rare, but devastating disorders caused by genetic mutations. Today they are largely impossible to treat in meaningful ways other than palliative care. Some …

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Americans relatively more comfortable with human cloning

February 1, 2021 / By / 1 Comment
Gallup-cloning

What is morally acceptable and where do we draw the line at behaviors that might just go too far such as human reproductive cloning? Over the years American attitudes have shifted on a number of potentially hot button moral behaviors including reproductive human cloning and pollsters including Gallup have tracked these attitudes. Gallup just came out …

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Genetic Modification of Humans Now Inevitable?

February 1, 2021 / By / 2 Comments
egg-edit

Discussion of concerns over heritable human genetic modification has spiked in 2015. This dialogue is a good thing, but is it in a sense too late? Are genetically modified (GM) people a foregone conclusion? Rumors are swirling that upwards of four papers reporting production of GM human embryos are in various stages of review at high-profile …

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Weekend Reads: Cool Papers, PubPeer, Jacob Hanna, & More

February 1, 2021 / By / 3 Comments
journals1

Here are some papers and news for weekend reads. What are you reading this weekend? What are your go-to stem cell journals? Hostile Takeover: Glioma Stem Cells Recruit TAMs to Support Tumor Progression by Yu Shi, Yi-fang Ping, Xia Zhang, Xiu-wu Bian in Cell Stem Cell. YAP1 Regulates OCT4 Activity and SOX2 Expression to Facilitate self-renewal and …

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