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Live Blogging #GeneEditSummit Day 2 Post #1: Governance of human gene editing

December 2, 2015 / Professor Paul Knoepfler, Ph.D.

Now we have an interesting panel starting on questions of governance on human gene editing. This will focus on institutional and national levels of governance. Pilar N. Ossorio, University of Wisconsin, Madison, and Morgridge Institute for Research, is introducing the panel. Key question: how should emerging technologies being governed? Jonathan Kimmelman, from McGill, was the first […]

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Steven Pinker interview: case against bioethocrats & CRISPR germline ban

August 10, 2015 / Professor Paul Knoepfler, Ph.D. / 15 Comments

CRISPR-Cas9 gene editing technology is red-hot right now and I’ve been doing interviews with various thought leaders on it, which today includes Steven Pinker. This technology has great power for research in the lab and there are hypothetical transformative clinical applications of CRISPR too. The latter efforts could include experimental attempts at reversal of disease-causing

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4 areas of debate on 1st human embryo genetic modification paper

April 27, 2015 / Professor Paul Knoepfler, Ph.D. / 5 Comments

Last week was a big one for the life sciences in that we saw the milestone of the first ever published paper reporting human embryo genetic modification (see here and here). It was one of those situations where we knew it was coming, but it was still a jolt. Not surprisingly this event sparked intense discussion

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Juan Carlos Izpisua Belmonte Cell Paper on Gene Editing for Mitochondrial Disease

April 23, 2015 / Professor Paul Knoepfler, Ph.D. / 2 Comments

The Juan Carlos Izpisua Belmonte group published a Cell paper today on using gene editing to reverse mutations associated with human mitochondrial disease. The paper is Reddy, et al. and is entitled, “Selective Elimination of Mitochondrial Mutations in the Germline by Genome Editing”. The authors report success using TALEN-based gene editing or mitochondrial-direct restriction enzyme (mito-ApaLI)

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ISSCR calls for moratorium on clinical application of human germline nuclear genome editing

March 19, 2015 / Professor Paul Knoepfler, Ph.D.

The International Society for Stem Cell Research (ISSCR) just now released a new policy statement on human germline gene editing. The statement calls for a ban on clinical application of human germline gene editing technology. Here is the brief summary statement at the beginning: The International Society for Stem Cell Research calls for a moratorium on

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Readers across the globe favor moratorium on gene editing of human germ cells in poll

March 18, 2015 / Professor Paul Knoepfler, Ph.D.

In a still ongoing on-line poll, readers of this blog show a pattern of consistently favoring a moratorium on genetic modification of human germ cells. With more than 150 votes cast, the top two answers are ‘strongly favor’ and ‘favor’ a moratorium on human germline genetic modification. Only 15% strongly opposed a moratorium. Overall those

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George Church on Germline Human Genetic Modification

March 9, 2015 / Professor Paul Knoepfler, Ph.D. / 17 Comments

I recently interviewed leading genomics scientist George Church on the ways that trends in genomics are changing our world. We also discussed the possibility of heritable human genetic modification. These days we more often call this “CRISPR babies.” His answers suggest that genomics and gene editing are poised to radically change our world. They could literally

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The Odd Couple of Cloning Research: Mitalipov & Woo Suk Hwang Unite

February 11, 2015 / Professor Paul Knoepfler, Ph.D. / 13 Comments

Remember that old TV show the Odd Couple with very proper Felix Unger and his polar opposite Oscar Madison who has all kinds of baggage? They’ve cloned it into a remake to be on TV soon here in the US in 2015. It seems only fitting then that actual human cloning research has a new

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Human GMO Method Given OK by UK Parliament in Historic Vote

February 3, 2015 / Professor Paul Knoepfler, Ph.D. / 4 Comments

The UK Parliament just voted to legalize the production of genetically modified human beings. To my knowledge, this is the first time in history that such a vote has given the green light to make GMO human beings in any country of the world. There are other hurdles before this method can actually be used including the

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When the state & ‘rogue’ scientists collide: case of China & CRISPR baby guy He Jiankui (贺建奎)

January 6, 2019 / Professor Paul Knoepfler, Ph.D. / 4 Comments

What happens next to He Jiankui (贺建奎) or as some people now refer to him, the “CRISPR baby guy”? China has a challenging situation to resolve here, but such conflicts between scientists and governments have happened regularly in history. When scientists go “rogue” (i.e. don’t conform to norms or ethical standards in an extreme way or

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