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Counterpoints to Lovell-Badge & Daley’s CRISPR baby rationales

February 11, 2019 / Professor Paul Knoepfler, Ph.D. / 5 Comments

Two prominent scientists, Robin Lovell-Badge and George Daley, have been amongst the most outspoken proponents of leaving the door open to heritable human genetic modification via CRISPR. While they each have articulated their reasons in somewhat different ways at times, their core reasons arguing in favor of future heritable CRISPR appear largely the same. In […]

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Why CRISPR baby production (if it happened) was unethical & dangerous

November 26, 2018 / Professor Paul Knoepfler, Ph.D. / 8 Comments

Jiankui-He-who-claims-CRISPR-baby-production

Reports are out that a scientist in China has been working to make a CRISPR baby for some time and supposedly has made twin genetically modified babies. I see this work as unethical and dangerous. Just a couple years ago when I published my book GMO Sapiens on potential use of CRISPR in a heritable manner

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Weekly reads: UC Davis Medical School diversity, CRISPR, Parkinson’s

March 26, 2023 / Professor Paul Knoepfler, Ph.D. / 2 Comments

It’s been almost seventeen years that I’ve been a professor here at UC Davis Medical School. It feels like home. I enjoy teaching our first-year medical students each year. Some end up doing research in my lab. Our school recently got a nice write-up over at STAT News by Usha Lee McFarling on the diversity

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‘We don’t want to freak people out’: about that Jacob Hanna human embryo model startup

August 18, 2022 / Professor Paul Knoepfler, Ph.D. / 5 Comments

Stem cell biologist Jacob Hanna has a new startup called Renewal Bio. Its goal is to harvest cells or tissues from human embryo or fetus models for clinical use. I believe that their commercial ambitions have so far outstripped careful thought and discussion in the broader community of researchers. There are major risks here for

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Stem cell reads: regeneration, 8C, MYC, CRISPR babies

February 27, 2022 / Professor Paul Knoepfler, Ph.D. / Leave a Comment

Another busy week including on the grant writing treadmill or should I say Mobius strip, but I’m always on the lookout for new reading and this week a lot popped up on regeneration. Also, a paper on healing and scarring. I regularly write about stem cell journals. For a long time, it seems like Cell Stem

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16 predictions for stem cells & regenerative medicine in 2022

January 4, 2022 / Professor Paul Knoepfler, Ph.D. / 4 Comments

The last few years in the stem cell and regenerative medicine arena have been complicated in many ways. Variables like surging stem cell clinics and COVID have made predictions harder. Even so, trying to make predictions is useful and it’s fun to go over past year’s predictions. You can see my scorecard on my 2021

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Grading my 21 stem cell & regenerative medicine predictions for 2021

December 22, 2021 / Professor Paul Knoepfler, Ph.D. / 3 Comments

The world of stem cell research and regenerative medicine is unpredictable but it’s fun to be a part of it and try to do predictions. Each year in late December or early January I make prognostications for the coming year for stem cell research and regenerative medicine. I made 21 such predictions for the current

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Regenerative reads: 3 CRISPR babies, FDA warning, diabetes, pubs

November 28, 2021 / Professor Paul Knoepfler, Ph.D. / 3 Comments

If you celebrate the Thanksgiving holiday I hope you had a nice one and, right before it started a new article popped on the scene about the CRISPR babies. Before we discuss those three gene-edited people, who are now growing up into little kids, we hit a milestone on our YouTube Stem Cell Channel with

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Weekly reads: stem cells to gametes, no PRP benefit, WHO CRISPR, pubs

July 18, 2021 / Professor Paul Knoepfler, Ph.D. / 7 Comments

The paper of the week is from Science on making ovarian follicles and actual eggs from stem cells. It’s just in mice, but this line of work tends to stir people up. We’ll dive into that in a moment. But first some good news. We’re up to 146 subscribers on our stem cell YouTube channel

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Weekly reads: escape to New York, CRISPR baby patents, ISSCR guidelines, pubs

May 30, 2021 / Professor Paul Knoepfler, Ph.D. / 1 Comment

My to-read list this weekend includes a range of papers along with various news & media including a report of two US research groups aiming to get CRISPR baby patents. More on that below. At long last a trip + fun thing to do in NYC Last week I took my first trip in more

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