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Countering that Pro-Heritable Human CRISPR WSJ Piece

October 22, 2017 / Professor Paul Knoepfler, Ph.D. / 9 Comments

It’s germline, heritable human CRISPR time, right? Wrong. But the particularly enthusiastic supporters of heritable human CRISPR often cite hypothetical benefits in glowing terms, but either don’t mention risks or strongly downplay them. These fans also tend to leave alternative, proven and safe technologies such as preimplantation genetic diagnosis (PGD) out of the discussion or […]

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CRISPR, human genetic modification, & a needed course correction

June 26, 2017 / Professor Paul Knoepfler, Ph.D. / 9 Comments

Are designer babies made using CRISPR or other genetic modification technologies closer to reality today? If so, what exactly should we do about it? Researchers can use CRISPR to genetically modify just about any organism or its cells, but targeting humans is the subject of the most intense discussion including using CRISPR in the human germline

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Clinics can’t retract problems like stem cell facelift gone wrong

January 4, 2017 / Professor Paul Knoepfler, Ph.D. / 8 Comments

What happens for patients and clinics after a stem cell facelift gone wrong? What about other cell injection problems? Cell therapies raise new challenges and risks. You can stop taking a pill or an injection treatment. However, you can’t stop or retract stem cell treatments if there’s a bad side effect. Unlike other kinds of

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Cynata approval for 1st ever allo trial of IPSC-derived MSCs for GVHD

September 22, 2016 / Professor Paul Knoepfler, Ph.D. / 6 Comments

Cynata Therapeutics Limited has received approval from UK regulators to start a first-of-its-kind allogeneic IPSC-based trial of MSCs for graft versus host disease (GVHD). Cynata also had some big news a couple weeks back with a deal with Fujifilm. The company is aiming to recruit 16 patients to test whether the MSCs (a type of adult

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In Depth Report from April 29th Paris Human Gene Editing Meeting

May 11, 2016 / Professor Paul Knoepfler, Ph.D.

Editor’s note. Caroline Simons attended both the April 28th (see her report on that here) and 29th Paris meetings on human gene editing/genetic modification. Today, we have her in depth report on the April 29th meeting. I have posted her piece in full with only minor edits. If you are in a rush you can

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Stem cell myths: they are homologous to everything

April 20, 2016 / Professor Paul Knoepfler, Ph.D. / 10 Comments

Some stem cell clinics sometimes use questionable ideas to bypass FDA regulations and I’d go far as to say some of these are outright stem cell myths. One such argument that seems like a myth in my opinion relates to the idea of “homologous use”, which is one of the hottest issues in stem cells in the clinical arena right

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Good reasons to go to the World Stem Cell Summit

November 16, 2015 / Professor Paul Knoepfler, Ph.D. / 3 Comments

By Heather Main This year I will be attending the World Stem Cell Summit for the first time (see @WSCSummit on Twitter). I was surprised when I looked at the program and recognized so few of the names of speakers; which made me question what this event was about, if not focused on stem cell research.

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Do Patients Have a Fundamental Right to Choice?

May 14, 2015 / Professor Paul Knoepfler, Ph.D. / 9 Comments

What is the “proper” amount of freedom of choice for patients in medicine? What if the treatments in question are experimental and come with their own baggage of associated risks, personal costs, and potential costs to society? More broadly, do patients have a fundamental right to medical choice? These questions seem particularly appropriate today on

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Ear-itating: Awesome John Oliver Invokes Vacanti Mouse While Blistering Dr. Oz

June 24, 2014 / Professor Paul Knoepfler, Ph.D. / 2 Comments

What is the Vacanti Mouse? Comedian John Oliver has an absolutely blistering segment (see below) on Dr. Oz in which he skewers the physician huckster. The video includes incredibly telling Oz testimony before Congress in which the celebrity doctor seems frankly pretty pathetic and cannot answer even simple questions about his selling of arguably snake oil on

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STAP April Update: Super Stressful on All Fronts

April 7, 2014 / Professor Paul Knoepfler, Ph.D. / 14 Comments

What’s going on with the STAP cell situation now that it is into its third month? It’s getting worse instead of better or clearer, at least in part due to RIKEN’s incomplete investigation. What’s going on with STAP? New RIKEN Press Conference RIKEN reportedly held an odd sort of limited press conference today that TJO

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