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Paper sparks renewed interest in transdifferentiation & clinical potential

September 8, 2022 / Professor Paul Knoepfler, Ph.D. / 1 Comment

There was a time when I thought transdifferentiation based approaches might quickly move into clinical trials. Then things kind of cooled off. We didn’t see many papers reporting methods to transdifferentiate cells. I still think that this technology, sometimes called direct reprogramming, has major potential. A new paper on making human brain cells this way got […]

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Weekly reads: $1B Saudi anti-aging push, OCT4 necklace, cancer trial wows, coffee brain

June 12, 2022 / Professor Paul Knoepfler, Ph.D. / 1 Comment

I recently wrote about stem cell-related ideas for anti-aging and even cheating death, but there are of course other approaches including drugs like metformin. A new article outlines a massive research funding plan to tackle aging. Let’s start with that. Recommend reads including anti-aging Saudi Arabia plans to spend $1 billion a year discovering treatments to

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Weekly reads: hydra heads, iblastoids, new 8-year grants

December 19, 2021 / Professor Paul Knoepfler, Ph.D. / Leave a Comment

What if you could get 8-year grants to do whatever biomedical research you wanted? This sounds like a dream for many of us in the life sciences, but the first news item this week is all about such a potential new funding approach. The item especially caught my eye as I’m going to be doing

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Weekly reads: vision, MyoD, liver regen, more

September 5, 2021 / Professor Paul Knoepfler, Ph.D. / 2 Comments

fish-eyes-from-stem-cells, stem cells for vision

I love stem cell research but experiments that have practical possible future applications in medicine like for vision loss are especially interesting to me. On the other hand basic research on core transcription factor mechanisms like by MyoD also really grab me. We cover some of this stuff and other ground in today’s recommended reads.

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New lab-grown blastoids are strikingly similar to human embryos

March 17, 2021 / Ricki Lewis / 2 Comments

A new word has been added to the lexicon of human stem cell research – blastoids, aka “blastocyst-like structures.” Unlike the familiar three-layered embryo that emerges during the third week of prenatal development, the earlier blastocyst resembles a fluid-filled soccer ball, with a smear of cells on the interior face destined to develop into the

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Weekly reads & paper of the week: gene-editing vs. aging

January 10, 2021 / Professor Paul Knoepfler, Ph.D. / Leave a Comment

koblan et al 2020 nature gene editing progeria

The paper of the week reports using base-editing, a kind of gene-editing, to reverse mutations associated with rapid aging syndromes, generally called progeria, but there are a lot of other interesting pubs to recommend for reading this week. I go over it all in this post. Gene-editing to fight premature aging syndromes In vivo base

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Weekly reads: Alzheimer’s, dinosaur brains, teratoma, vampire amoeba, new H3K27me3 reader

November 8, 2020 / Professor Paul Knoepfler, Ph.D. / 1 Comment

Anyone with a seemingly only semi-functional nervous system now post-election might be turning to science to help their brains bounce back. Here are some of the things I’ve been reading or hope to soon. In good news for the stem cell and regenerative medicine field, especially here in California, it looks like us California voters

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Weekend recommended reads: Athersys, ALS, COVID-19, Fibroblasts, Zoom brain

August 9, 2020 / Professor Paul Knoepfler, Ph.D. / 3 Comments

What are you reading these days and does it include topics like cell therapies for COVID-19, ALS, regenerative potential of fibroblasts, and why Zoom meetings are so tiring for the brain? I cover those topics and more below with recommended reads including papers and media items. Here’s last week’s recommended reads. Here’s to fibroblasts, which

Regenerative medicine recommended reads including $191 million to researcher

March 8, 2020 / Professor Paul Knoepfler, Ph.D. / 4 Comments

Mark-Pennesi-CRISPR-regenerative-medicine-eye

It’s notable how the FDA now considers gene-editing a kind of regenerative medicine. This means that various gene therapy products in development technically qualify as regenerative therapies. Ever since the agency began its rapidly growing regenerative medicine advanced therapy (RMAT) designation program, we’ve seen an increasing number of gene therapy biotechs and products qualify as

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Interview with Fredrik Lanner who is CRISPR’ing healthy human embryos

September 26, 2016 / Professor Paul Knoepfler, Ph.D. / 2 Comments

ssistant-Professor-Fredrik-Lanner--e1474733944943

In the past year there has been a great deal of attention given to the potential use of CRISPR-Cas9 for gene editing in human embryos. An important recent development, described in a new NPR article by Rob Stein, is the use of CRISPR-Cas9 in healthy human embryos for developmental biology research by assistant professor Fredrik

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