Search Results for: china

Mitalipov Nature pub review: IPSC & SCNT for mitochondrial disease

February 1, 2021 / By / 6 Comments
Mitalipov-IPSC-paper

In a new, thought-provoking paper today in Nature, Shoukhrat Mitalipov and a multi-institutional team report a significant advance toward potential novel ways to treat mitochondrial diseases. What are these illnesses? Mitochondrial diseases are rare, but devastating disorders caused by genetic mutations. Today they are largely impossible to treat in meaningful ways other than palliative care. Some …

Mitalipov Nature pub review: IPSC & SCNT for mitochondrial disease Read More »

News bites & rumors on human embryo genetic modification

February 1, 2021 / By / 8 Comments
statment_gene_editing-tech

A lot has happened in the week since the first human embryo genetic modification paper was published by a team led by Junjiu Huang. There have been a number of new events just in the last few days. Jocelyn Kaiser over at SCIENCEINSIDER has a new piece reporting a couple important developments including that the journal …

News bites & rumors on human embryo genetic modification Read More »

4 areas of debate on 1st human embryo genetic modification paper

February 1, 2021 / By / 5 Comments
human-genetic-modification

Last week was a big one for the life sciences in that we saw the milestone of the first ever published paper reporting human embryo genetic modification (see here and here). It was one of those situations where we knew it was coming, but it was still a jolt. Not surprisingly this event sparked intense discussion …

4 areas of debate on 1st human embryo genetic modification paper Read More »

Concerns surface on Chinese paper on genetic modification of human embryos

February 1, 2021 / By / 5 Comments
GM-human-embryo-review

The paper that came out Wednesday from a research group in China reporting the first genetic modification of human embryos has sparked a lot of discussion. Some concerns about this paper have surfaced. 2-day review? The paper (HT to John Borghi) was in review only from March 30-April 1 — so at most 48 hours. Really? That certainly …

Concerns surface on Chinese paper on genetic modification of human embryos Read More »

The big blind spot on CRISPR for human embryo editing: PGD

February 1, 2021 / By / 10 Comments
blind-spot

There is a big old blind spot in the discussion over germline gene editing in humans: preimplantation genetic diagnosis (PGD). There’s been a lot of talk in 2015 about worries over how gene editing technology such as CRISPR might be used prematurely in the clinic in an unsafe or unethical manner in humans in the …

The big blind spot on CRISPR for human embryo editing: PGD Read More »

Juan Carlos Izpisua Belmonte Cell Paper on Gene Editing for Mitochondrial Disease

February 1, 2021 / By / 2 Comments
Figure-6B

The Juan Carlos Izpisua Belmonte group published a Cell paper today on using gene editing to reverse mutations associated with human mitochondrial disease. The paper is Reddy, et al. and is entitled, “Selective Elimination of Mitochondrial Mutations in the Germline by Genome Editing”. The authors report success using TALEN-based gene editing or mitochondrial-direct restriction enzyme (mito-ApaLI) …

Juan Carlos Izpisua Belmonte Cell Paper on Gene Editing for Mitochondrial Disease Read More »

Genetic Modification of Humans Now Inevitable?

February 1, 2021 / By / 2 Comments
egg-edit

Discussion of concerns over heritable human genetic modification has spiked in 2015. This dialogue is a good thing, but is it in a sense too late? Are genetically modified (GM) people a foregone conclusion? Rumors are swirling that upwards of four papers reporting production of GM human embryos are in various stages of review at high-profile …

Genetic Modification of Humans Now Inevitable? Read More »

Tips for Visiting Stockholm During ISSCR 2015 by Heather Main

February 1, 2021 / By
Stockholm-Sweden-Riddarholmen-ChurchBy-Unknown

Note that you can register for ISSCR Stockholm here and the early registration deadline is today, March 11. Even without ISSCR Stockholm is a city worth visiting! There is no Eiffel Tower, Colosseum or Big Ben but Stockholm is one of Europe’s best kept secrets and the most beautiful European city I have visited. This …

Tips for Visiting Stockholm During ISSCR 2015 by Heather Main Read More »