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Monkeying around with myostatin: on the road to healthier humans or human hulks?

October 25, 2015 / Professor Paul Knoepfler, Ph.D. / 6 Comments

The myostatin gene has been getting quite a bit of attention lately. The buzz surrounds the idea of inhibiting myostatin either through gene therapy or via germline human genetic modification. In this way, some hope to create people with more muscle. Myostatin, which also goes by the acronym MSTN, has an inhibitory function on muscle. […]

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Noah’s GMO ark: is it ethical to create GM or cloned animals for sale as pets?

October 21, 2015 / Professor Paul Knoepfler, Ph.D. / 8 Comments

CRISPR-ful Noah’s Ark? Even as much of the discussion surrounding powerful new gene editing and cloning technologies has centered on their possible use in humans, the creation of genetically modified (GM) and cloned animals has advanced at warp speed. Some of these efforts have been for research, which is justified. But many seem profit-centered and

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UK Biologist Kathy Niakan Asks to Make GM Human Embryos For Research

September 18, 2015 / Professor Paul Knoepfler, Ph.D. / 4 Comments

UK biologist Kathy Niakan has asked governmental permission to make GM human embryos using CRISPR. Earlier this year, a research team in China crossed a scientific line for the first time in history by using gene editing technology called CRISPR-Cas9 to make genetically modified (GM) human embryos. Other researchers around the world including now one

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NAS Meeting on Human Germline Modification Taking Shape

September 14, 2015 / Professor Paul Knoepfler, Ph.D. / 4 Comments

The US National Academy of Sciences (NAS) will hold a meeting on heritable human germline modification on December 1-3, 2015 in Washington, D.C. Invitations to the NAS meeting to individuals starting going out last week. The upcoming NAS meeting seeks to address these issues and discuss the possibility of a moratorium on clinical use of

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Mitalipov Nature pub review: IPSC & SCNT for mitochondrial disease

July 15, 2015 / Professor Paul Knoepfler, Ph.D. / 6 Comments

In a new, thought-provoking paper today in Nature, Shoukhrat Mitalipov and a multi-institutional team report a significant advance toward potential novel ways to treat mitochondrial diseases. What are these illnesses? Mitochondrial diseases are rare, but devastating disorders caused by genetic mutations. Today they are largely impossible to treat in meaningful ways other than palliative care. Some

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Stem Cell Meetings & Conferences 2016

July 7, 2015 / Professor Paul Knoepfler, Ph.D. / 24 Comments

Below is a list of upcoming stem cell and regenerative medicine conferences and meetings for 2016. If you do not see your meeting, please let me know and I will include it. This list is meant to be as inclusive as possible, but by listing specific events I am not necessarily endorsing them. January Molecular

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News bites & rumors on human embryo genetic modification

April 30, 2015 / Professor Paul Knoepfler, Ph.D. / 8 Comments

A lot has happened in the week since the first human embryo genetic modification paper was published by a team led by Junjiu Huang. There have been a number of new events just in the last few days. Jocelyn Kaiser over at SCIENCEINSIDER has a new piece reporting a couple important developments including that the journal

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4 areas of debate on 1st human embryo genetic modification paper

April 27, 2015 / Professor Paul Knoepfler, Ph.D. / 5 Comments

Last week was a big one for the life sciences in that we saw the milestone of the first ever published paper reporting human embryo genetic modification (see here and here). It was one of those situations where we knew it was coming, but it was still a jolt. Not surprisingly this event sparked intense discussion

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Concerns surface on Chinese paper on genetic modification of human embryos

April 25, 2015 / Professor Paul Knoepfler, Ph.D. / 5 Comments

The paper that came out Wednesday from a research group in China reporting the first genetic modification of human embryos has sparked a lot of discussion. Some concerns about this paper have surfaced. 2-day review? The paper (HT to John Borghi) was in review only from March 30-April 1 — so at most 48 hours. Really? That certainly

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The big blind spot on CRISPR for human embryo editing: PGD

April 24, 2015 / Professor Paul Knoepfler, Ph.D. / 10 Comments

There is a big old blind spot in the discussion over germline gene editing in humans: preimplantation genetic diagnosis (PGD). There’s been a lot of talk in 2015 about worries over how gene editing technology such as CRISPR might be used prematurely in the clinic in an unsafe or unethical manner in humans in the

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