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Juan Carlos Izpisua Belmonte Cell Paper on Gene Editing for Mitochondrial Disease

April 23, 2015 / Professor Paul Knoepfler, Ph.D. / 2 Comments

The Juan Carlos Izpisua Belmonte group published a Cell paper today on using gene editing to reverse mutations associated with human mitochondrial disease. The paper is Reddy, et al. and is entitled, “Selective Elimination of Mitochondrial Mutations in the Germline by Genome Editing”. The authors report success using TALEN-based gene editing or mitochondrial-direct restriction enzyme (mito-ApaLI) […]

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Concerns flying on human embryo editing papers

April 9, 2015 / Professor Paul Knoepfler, Ph.D. / 1 Comment

We’ve all heard the human embryo editing rumors. There is a sense that human embryos have already been CRISPR’d. Rumors are rumors and they may mean not a whole lot, but there definitely is a huge buzz on this right now both in a positive sense and with concern. The excitement is over the power of

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Genetic Modification of Humans Now Inevitable?

March 29, 2015 / Professor Paul Knoepfler, Ph.D. / 2 Comments

Discussion of concerns over heritable human genetic modification has spiked in 2015. This dialogue is a good thing, but is it in a sense too late? Are genetically modified (GM) people a foregone conclusion? Rumors are swirling that upwards of four papers reporting production of GM human embryos are in various stages of review at high-profile

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Tips for Visiting Stockholm During ISSCR 2015 by Heather Main

March 11, 2015 / Professor Paul Knoepfler, Ph.D.

Stockholm-Sweden-Riddarholmen-ChurchBy-Unknown

Note that you can register for ISSCR Stockholm here and the early registration deadline is today, March 11. Even without ISSCR Stockholm is a city worth visiting! There is no Eiffel Tower, Colosseum or Big Ben but Stockholm is one of Europe’s best kept secrets and the most beautiful European city I have visited. This

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The Odd Couple of Cloning Research: Mitalipov & Woo Suk Hwang Unite

February 11, 2015 / Professor Paul Knoepfler, Ph.D. / 13 Comments

Remember that old TV show the Odd Couple with very proper Felix Unger and his polar opposite Oscar Madison who has all kinds of baggage? They’ve cloned it into a remake to be on TV soon here in the US in 2015. It seems only fitting then that actual human cloning research has a new

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Open letter to UK Parliament: avoid historic mistake on rushing 3-parent technology

November 2, 2014 / Professor Paul Knoepfler, Ph.D. / 1 Comment

Dear UK Parliament and Science and Technology Committee, I am writing to you about your deliberations on “mitochondrial donation” (also known as 3-parent technology) intended for the purpose of preventing heritable mitochondrial disorders. I am concerned about the Department of Health’s recent draft regulations that would allow 3-parent experiments to go forward and the possibility that the UK

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Interview with Neuralstem CEO Richard Garr

September 8, 2014 / Professor Paul Knoepfler, Ph.D. / 1 Comment

I invited Neuralstem CEO, Richard Garr, to do a Q&A interview and he kindly accepted. The interview provides some novel insights into this major biotech in the stem cell sector. 1. How is Neuralstem doing today? What programs are underway that you find particularly exciting? Garr: Neuralstem is moving on all cylinders these days on

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Stem Cell Meetings & Conferences 2015

September 3, 2014 / Professor Paul Knoepfler, Ph.D. / 21 Comments

Below is a list of upcoming stem cell and regenerative medicine conferences and meetings in 2015. If you do not see your meeting, please let me know and I will include it. This list is meant to be as inclusive as possible, but by listing specific events I am not necessarily endorsing them. Enjoy! January

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Five possible natural stem cell boosts (but do your homework)

July 16, 2014 / Professor Paul Knoepfler, Ph.D. / 4 Comments

What might be some natural stem cell boosts? How might we all increase the number or helpful activities of our own stem cells? If possible isn’t that a better, simpler, & safer idea than getting a transplant of stem cells? Think of it as preventative medicine via stem cells. Note that this post was updated

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Did Clone-Like Nature & Science Pieces Boost Hwang Redemption PR Effort?

January 16, 2014 / Professor Paul Knoepfler, Ph.D. / 1 Comment

There was a Twitter buzz yesterday about a Science news story on Korean cloning fraud Woo Suk Hwang’s efforts for redemption in the scientific community. What was the big deal? It turns out to be a peculiar situation. The Science Hwang piece by Dennis Normile, entitled “After Fraud, Korean Cloner Seeks Redemption”, was eerily similar in

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