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Future of Somatic Cell Nuclear Transfer to make ES Cells

November 9, 2014 / Professor Paul Knoepfler, Ph.D. / 3 Comments

Advances in therapeutic cloning reported in the past year have been very exciting as somatic cell nuclear transfer (SCNT) can be used to produce very powerful human embryonic stem cells (ESC). These new cells are called NT-ESCs for short. Neither embryos nor reprogramming factors are needed to produce human NT-ESCs. See here, here and here for discussions of the pioneering papers reporting creation of […]

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Interview with StemCells Inc. leadership on hot topics

August 31, 2014 / Professor Paul Knoepfler, Ph.D. / 5 Comments

StemCells Inc. is a top biotech company developing stem cell-based therapies. They have a deep pipeline that includes already ongoing trials for a variety of diseases. I invited company leadership to do an interview and they graciously accepted. Below is the interview with CFO Greg Schiffman (picture at left from LinkedIn) including what I thought

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Challenge tries to cancel Yamanaka iPS cell patent

August 14, 2014 / Professor Paul Knoepfler, Ph.D. / 66 Comments

A new patent dispute has exploded in the stem cell field related to induced pluripotent stem (iPS) cells. What’s going on? In 2006, Shinya Yamanaka reported cellular reprogramming to create mouse induced pluripotent stem (iPS) cells in Cell and the next year multiple groups along with Yamanaka’s reported creating human iPS cells. It’s no exaggeration

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Review of Mitalipov Nature paper: cloned ES cells vs iPS cells

July 2, 2014 / Professor Paul Knoepfler, Ph.D. / 5 Comments

Just how good are human embryonic stem (ES) cells made by therapeutic cloning via nuclear transfer, with the successful technique first reported by the lab of Shoukhrat Mitalipov at OHSU last year? How do they compare to induced pluripotent stem (iPS) cells or traditional ES cells made from IVF embryos? A new paper in Nature directly tackles these

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Past Time for Nature to Retract STAP Cell Pubs, Open up on Review Problems

May 27, 2014 / Professor Paul Knoepfler, Ph.D. / 9 Comments

Two stem cell papers riddled with errors, with figures that resulted from potential misconduct, with plagiarism, and with other serious problems remain uncorrected and unretracted in the prestigious journal Nature. It is well past time for the journal to editorially retract them. It was about four months ago that Nature published the two astonishing STAP papers reporting the

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Review of Obokata STAP cells Nature papers

January 29, 2014 / Professor Paul Knoepfler, Ph.D. / 23 Comments

In two Nature papers (here and here) published today researchers report the astounding finding of reprogramming differentiated cells back to a pluripotent or even totipotent state simply by exposing the cells to extreme environmental stress, creating cells they called STAP cells. Update: see more thoughts on STAP stem cells here. STAP cells: stressing the cell

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Review of New Yamanaka Paper on Defective iPS cells

November 21, 2013 / Professor Paul Knoepfler, Ph.D. / 11 Comments

A team led by Shinya Yamanaka has published a new study reporting analysis of defective induced pluripotent stem (iPS) cells in the journal PNAS. Part of what I liked so much about this paper is that it tackled a very real, but controversial area of stem cell research. By this I mean the reality that a

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Nominees for Stem Cell Person of the Year 2013: scientists, advocates, physicians, and the Pope

October 1, 2013 / Professor Paul Knoepfler, Ph.D. / 3 Comments

Nominations for Stem Cell Person of the Year 2013 closed last night and I ended up with a remarkable list of 30 nominees. I have included a few sentences about each one below, often taking verbiage directly from the nominator. The online voting on these nominees will start soon. The top vote getters will move

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Hisashi Moriguchi 2.0: more papers, more claims, and a new mysterious co-author

June 14, 2013 / Professor Paul Knoepfler, Ph.D. / 2 Comments

Remember Hisashi Moriguchi? He’s the fellow who claimed to have transplanted cells made from induced pluripotent stem (iPS) cells into human patients, to have worked at Harvard, and so forth. It all turned out not to be true. He even admitted it. Now Moriguchi is back in the news. He has several more papers published

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Putting the IP in iPS cells: patent war looming?

May 13, 2013 / Professor Paul Knoepfler, Ph.D. / 20 Comments

Will intellectual property (IP) wars over patent rights to one of the most exciting new stem cell technologies hold back getting novel therapies to patients such as IPS cells? Unfortunately, it’s very possible. Induced pluripotent stem (iPS) cells are very cool stem cells made from non-stem cells through a process called cellular reprogramming. iPS cells

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