Search Results for: direct reprogramming

Weekly reads: lab meat, crow brain biology, direct reprogramming, more

Stacho-et-al-Science-2020-Fig-1small

Does time seem somewhat warped to anyone else in 2020 even without having  had COVID, which could alter brain function? It just seems like with everything going on that time simultaneously both drags and zooms by this year. One sort of reassuring element is that papers keep on being published so we can enjoy cool …

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Big stem cell news: dynamic duo of all-chemical direct reprogramming reports

Neurons-created-from-ciNSC

There’s some big, positive news on the stem cell front today. Two new innovative papers both by teams led by Sheng Ding of Gladstone Institutes with UCSF report all-chemical direct reprogramming of human somatic cells. Ding’s team took skin cells and by exposing them to cocktails of small molecules was able to turn them directly into …

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Transdifferentiation makes a major advance: direct reprogramming of fibroblasts to oligodendrocyte progenitors

Back-to-back papers (here and here) in Nature Biotechnology report the transdifferentiation (now often simply referred to as “direct reprogramming”) of plain old fibroblasts into brain cells called oligodendrocyte progenitor cells (OPCs). OPCs are a remarkably useful kind of brain cell that generates myelin, which insulates nerves. OPCs are thought to have great therapeutic potential for …

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Recommended reads: a tale of human tails, heart reprogramming, pericytes, microglia

humans with tails

A piece on human tails and how we lost them caught my eye so I’ll start my weekly reads with that. This week I had the fewest Zoom meetings in ages, which allowed me to get more work done in my own lab and more reading. How about that? I even had some in-person meetings …

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Sherley patent for reprogramming method like STAP cells

ASCTC

A new patent has been awarded to James Sherley for a very unusual method claimed for making induced pluripotent stem (iPS) cells. The patent, No. 8,759,098, claims that a single non-genetic chemical agent, xanthine, can by itself reprogram adult stem cells (ASC) into iPS cells (aka iPSCs; see image they released at left). Surprising patent, huh? Another …

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Cool Cell Stem Cell Paper From Ishii Team on Histones & Reprogramming

Two of my favorite things are stem cells and histones. When they both come together in one paper and it’s in my favorite journal, Cell Stem Cell, you’ve got my full attention. My own lab is especially interested in the roles of histones and Myc in stem cells. So when I saw a paper a paper from …

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Jacob Hanna on Radically Deterministic Reprogramming @TMM2013

What is “radically deterministic” cellular reprogramming? Jacob Hanna’s lab recently published a very high profile Nature paper on nearly 100% efficient iPS cell formation based on targeting a factor called Mbd3. This super efficiency is a major departure from past reported efficiencies. This morning here at the Till & McCulloch Stem Cell Meeting in Banff, …

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What do you think of all chemical reprogramming? Take our poll

How important is the new development of all chemical reprogramming to make iPS cells? The group led by Hongkui Deng at Peking University in Beijing reported in Science that they used 7 chemicals to make what appear to be mouse iPS cells. I’m hearing a wide range of opinions directly from people in the know. What’s …

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What are induced pluripotent stem cells or IPS cells & clinical prospects?

induced pluripotent stem cells clinical trials map

Induced pluripotent stem cells or IPS cells just might be the most exciting development in the stem cell field over the last 15 years. They have unique potential for clinical impact for regenerative medicine too, both through their use to produce differentiated cellular therapies and indirectly via disease modeling as well as drug screening. The …

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21 Stem Cell Research & Regenerative Medicine 2021 Predictions

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In any given field of biomedical science like stem cell research and regenerative medicine, it’s very useful if you can accurately predict the future. It seems, though, that predictions are far more difficult within the more exciting and rapidly-changing fields. The field of stem cells and regenerative medicine fits that bill. Past stem cell research …

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