Search Results for: Gene Editing

Weekly reads: stem cell good news, bad news on sickle cell, MS, IPSCs

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victoria gray family crispr sickle cell b

Let’s start with some stem cell good news on evolving approaches to treat sickle cell disease involving stem cells. Then on another related front things were more concerning. Stem cell good news on sickle cell disease, a complication Sickle Cell Disease News reports Adding Briquilimab Boosts Success of Sickle Cell Stem Cell Transplant. This is a […]

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He Jiankui says he’s back in the lab after prison for CRISPR babies

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He Jiankui

Earlier this year Chinese researcher He Jiankui finished his prison sentence. When I saw that news I wondered about the next chapter for him. It seems he’s already back in the lab doing genetics research. At least that’s according to a blog by He Jiankui himself. Can we trust that what he has written on his website is

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Weekly reads: Gamida Cell, Siddhartha Mukherjee, CRISPR in viruses

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Abigail L. Jenkins, Gamida Cell

Hematopoietic stem cells have many clinical applications and a company called Gamida Cell has an interesting product in this area called Omidubicel that may have several applications.  I’m going to start the weekly reads with news there. Gamida Cell and the FDA A recent piece discussed how Omidubicel is progressing with the FDA. FDA extends

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Updates on CRISPR therapy development and clinical trials

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When I first heard of CRISPR gene editing I was excited for my lab to try it out, but it seemed a long way from the field having even one CRISPR therapy available to treat human disease. In the Knoepfler lab, we study genetic and genomic programming in human development and disease. Gene editing seemed

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Weekly reads: death in CRISPR trial, sickle cell, nose picking & dementia, epilepsy

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CRISPR gene editing

As both a scientist who works on stem cells, cancer, and CRISPR, and a research advocate I’ve been fortunate to meet many patient advocates over the years. Some have been participants in clinical trials themselves. Benefits & risks of clinical trial participation It is very sobering to find out that a clinical trial participant has

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Funny autocorrect fails in STEM: the gremlin organdy fiasco

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Germline gremlins, funny autocorrect fails

Today’s post is on the lighter side with some humor on funny autocorrect fails related to science. It’s surprising sometimes how far certain tools can lag behind cutting-edge science. Spellcheck tools are useful, of course, but they don’t always know what to do with STEM words. The same is true of tools like Grammarly, although it

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Weekly reads: upbeat stem cell clinical trials update, CRISPR ups & downs, story of 1st marrow transplant survivor

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stem cell clinical trials

It’s always great to read about stem cell clinical trials that are looking encouraging. Stem cell clinical trials Proving a new therapy is safe and effective is so challenging. Remarkably, there are more than 9,300 stem cell clinical trials listed for a “stem cell” search on Clinicaltrials.gov. Of course, not all of these are actual

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Recommend reads: CRISPR baby guy free, DNMT3, sperm, Editas, hearing loss, reprogramming

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Dura et al sperm development

We often don’t think of them that way but reproductive cells like sperm and egg are also relatives of stem cells, and it turns out that there are stem cells that make the reproductive cells too like sperm stem cells. Sperm and germ cell stem cells DNMT3A-dependent DNA methylation is required for spermatogonial stem cells

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Weekly reads: CAR-T cell good news, Califf fight, stem cells on lymph

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CAR-T-cell-infographic

Not everything in biomedical science is a ground-breaking discovery or clinical game-changer, but CAR-T cell technology is a combination of both. CAR-T cell good news We have such good news in this new pub on long-term benefits: Decade-long leukaemia remissions with persistence of CD4+ CAR T cells, Nature. Another recent CAR-T cell article, this one in Science,

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