It’s always great to read about stem cell clinical trials that are looking encouraging.
Stem cell clinical trials
Proving a new therapy is safe and effective is so challenging. Remarkably, there are more than 9,300 stem cell clinical trials listed for a “stem cell” search on Clinicaltrials.gov. Of course, not all of these are actual active interventional studies transplanting cells, but hundreds fit the bill.
If you limited the Clinicaltrials.gov search to actively recruiting interventional stem cell trials, the search still yields more than 1,300 listings. I’ve captured a map of these listings, which I’ve included below. Today I’m going to start off by talking about one specific trial that is groundbreaking.
I’m not involved in it, but a spina bifida stem cell clinical trial here at UC Davis has had my attention for years.
Now our local paper, The Sac Bee, reports on encouraging early results from the spina bifida trial. Some initial participants have done unexpectedly well, which is encouraging. There’s a long road ahead with the trial, which uses a cell therapy patch to protect the spinal cord during development. The leaders of the trial are my colleagues Drs. Diana Farmer and Aijun Wang. CIRM has provided key funding for this clinical work.
I’ve written before about this spina bifida trial and its preclinical work in bulldogs. You can see a pic of one of the dogs below. Bulldogs have a high rate of spontaneous spina bifida.
Some more recommended reads
CRY2 isoform selectivity of a circadian clock modulator with antiglioblastoma efficacy.”, PNAS. Inhibiting glioblastoma stem cells could be a major step toward an effective therapy.
Aplastic Anemia: Nancy Lowry – Longest Living Transplant Survivor, BMT Infonet. I didn’t know this, but Nancy was the recipient of the first successful bone marrow transplant and she’s still alive and doing well to this day. What a story.