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The main challenges for SCNT cloning of human embryonic stem cells

April 21, 2014 / Professor Paul Knoepfler, Ph.D. / 1 Comment

It was intriguing last week to read about another advance in somatic cell nuclear transfer (SCNT)-based therapeutic cloning of human embryonic stem cells (hESC). The first such work was published last year by Mitalipov’s group from OHSU. This second paper to produce so-called nuclear transfer hESC (NT-hESC) made the important advance to show that it could […]

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Adult human therapeutic cloning of embryonic stem cells by SCNT

April 17, 2014 / Professor Paul Knoepfler, Ph.D. / 4 Comments

An international team of stem cell scientists has replicated human therapeutic cloning to make embryonic stem cells via somatic cell nuclear transfer (SCNT). The team was led by Drs. Dong Ryul Lee of CHA Stem Cell Institute in Korea and Robert Lanza of Advanced Cell Technology (ACT). They reported the advance in the Chung, et

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Lessons from STAP cell fiasco so far

April 16, 2014 / Professor Paul Knoepfler, Ph.D. / 9 Comments

The ultimate fate of the two Nature STAP cell papers remains in troubled limbo. One of the senior STAP cell authors, Dr. Sasai, held a news conference yesterday in Japan that included a call for the papers to be retracted. He was variously quoted as believing in STAP cells or alternatively as just thinking it

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As Predicted, Big News For California Stem Cell, Inc.: Purchased by NeoStem

April 14, 2014 / Professor Paul Knoepfler, Ph.D. / 3 Comments

Late last year I was hearing some exciting things about California Stem Cell, Inc. under the leadership of Hans Keirstead. (2020 update: interestingly 3 years ago Keirstead ran for congress, but the campaign didn’t quite make it.) In fact, I thought a big move for California Stem was in the cards for 2014 and looking into

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After nightmare stem cell week, some good news?

April 13, 2014 / Professor Paul Knoepfler, Ph.D. / 7 Comments

We in the stem cell field should call this past week: A Nightmare on Stem Street. I can’t think of many weeks that have been worse for the stem cell field than this past one. I’m a new week is starting soon. It was a real nightmare, although I wish it was just something fictional

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Obokata STAP news conference: thoughts, questions & open discussion

April 9, 2014 / Professor Paul Knoepfler, Ph.D. / 45 Comments

Dr. Haruko Obokata held a news conference today in Japan about the STAP cell controversy. It was very painful to watch. I’m a softy so at moments I felt somewhat sad for her as I watched, but as a scientist I have to say the STAP situation has been very bad for the stem cell

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Apakah itu stem cell (sel punca)?

April 4, 2014 / Professor Paul Knoepfler, Ph.D. / 33 Comments

What does “Apakah itu stem cell (sel punca)” mean? This is part of our stem cells not lost in translation or SCOPE project: here we have a white paper in Indonesian “What are stem cells” that translates as “Apakah itu stem cell (sel punca)?” SCOPE has dozens of languages and has had millions of reads

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Wild History of VSELs Predicts Future of STAP Cells?

April 4, 2014 / Professor Paul Knoepfler, Ph.D. / 2 Comments

Very small embryonic-like stem cells aka VSELs are reported to be tiny adult stem cells that are pluripotent or non-existent depending on whom you talk to most recently or which paper you just read. These very controversial cells (which I once compared to the Sasquatch) have a wildly fluctuating history with their existence on multiple occasions

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STAP Cell Nature Papers: Cases For & Against Retraction

March 31, 2014 / Professor Paul Knoepfler, Ph.D. / 11 Comments

What next for STAP? Is retraction of the two papers on the near horizon? It has been two months now since Nature published the two papers on STAP cells and STAP stem cells. There has been a storm of controversy surrounding these papers and the claims they made to easily produce the most powerful of

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Què són les cèl·lules mare? Stem cells in Catalan

March 28, 2014 / Professor Paul Knoepfler, Ph.D. / 1 Comment

This piece in Catalan, Què són les cèl·lules mare?, was updated in 2021, and is part of our SCOPE stem cells not lost in translation project. You can learn more about the project and read the other 34 languages here. Què són les cèl·lules mare? Stem cells in Catalan El cos humà conté centenars de

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