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FDA chides US doc who genetically modified human embryo in reported 3-person IVF

August 4, 2017 / Professor Paul Knoepfler, Ph.D. / 1 Comment

The FDA sent a stern letter today to Dr. John Zhang, PhD, MD, the physician who last year created a genetically modified human embryo in the U.S. and then exported it to Mexico where he self-reported creating a genetically modified baby boy. While the genetically modified baby created in Mexico was reportedly seemingly OK, it’s not clear […]

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The Niche’s 2,000th post: where do we go from here?

July 6, 2017 / Professor Paul Knoepfler, Ph.D. / 5 Comments

2,000 is a big number. As of this week I’ve now published 2,000 posts here on The Niche since I started back in early 2010. I can’t quite believe it myself. To celebrate that milestone, I have revamped The Niche in terms of its organization and style with the help of a very skilled web

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Postdoc Job Opening: Cancer & Stem Cell Epigenomics Knoepfler Lab

July 5, 2017 / Professor Paul Knoepfler, Ph.D.

An NIH and foundation-funded postdoctoral fellow position in the Knoepfler Lab at UC Davis School of Medicine is open. The focus of research will be on cancer and stem cell epigenomics. Studies will include functional genomics assays such s ChIP-Seq, chromatin configuration, CRISPR genetics work, and cell biological research. Qualifications: Applicants must have a PhD,

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Hunting for computational approaches for stem cells at ISSCR2017

June 20, 2017 / Professor Paul Knoepfler, Ph.D. / 7 Comments

By Cátia Bandeiras, PhD Student at University of Lisbon, Portugal and Massachusetts Institute of Technology. See tweets from the conference using #ISSCR2017 @apulgarita I just wrapped up my stay at the Annual Meeting of ISSCR 2017, which happened in Boston. I decided to take advantage of the fact that I am living in Boston at

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2017 stem cell predictions: score card at 1/2-way point

June 18, 2017 / Professor Paul Knoepfler, Ph.D. / 1 Comment

In December of each year I make a list of stem cell predictions for the coming year, and I made 20 such predictions for 2017 so I’m wondering how I’m doing so far on these now that it’s June. Below is my work-in-progress scorecard for these so far. Positive news from Asterias on trial for stem cell-based

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Blog reader survey results & winner of the stem cell swag

May 22, 2017 / Professor Paul Knoepfler, Ph.D. / 2 Comments

It’s fun and useful for me to learn about the readers of this blog in terms of who they are and what their interests are in terms of the types of posts that I do. Below are the results of two recent reader surveys that I did to get this kind of information. The two

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10 takeaways from Future of Genomic Medicine meeting

March 6, 2017 / Professor Paul Knoepfler, Ph.D.

The Future of Genomic Medicine conference last week down in La Jolla at Scripps was one of my favorite meetings ever. I wish I had time to have live blogged it more beyond the one post I did about some gene editing talks. Below I discuss 10 top takeaways from this great meeting that I’m planning to attend

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Synthetic embryo or embryo model tech reported in Science: how big is this?

March 3, 2017 / Professor Paul Knoepfler, Ph.D. / 1 Comment

Can you make a synthetic embryo, also called an embryo model? Developmental biologist Magdalena Zernicka-Goetz has long been on the trail of this seemingly almost uncatchable quarry. With her team’s publication in Science today they took a big step forward on this path even if some major hurdles remain. You can see her discussion of

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Live blogging Future of Genome Medicine: great talks by Feng Zhang & others

March 2, 2017 / Professor Paul Knoepfler, Ph.D.

What is the future of Genome Medicine? The meeting by that same name that I’m at down here in La Jolla is all about tackling this question and the line up of speakers today on the first day is amazing. I’m speaking about IPS cells as a basis for personalized medicine tomorrow morning so that’s exciting.

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Q&A video with Paul Episode 1: your stem cell questions answered

February 26, 2017 / Professor Paul Knoepfler, Ph.D. / 6 Comments

Where is the stem cell field now and where the heck is it heading? There are hundreds of questions. Readers often email me questions or leave them as comments. It’s not unusual to get questions about CRISPR as well. As time permits, I’m hoping once or twice a month on Sundays to post a video answering

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