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Recommend reads: CRISPR baby guy free, DNMT3, sperm, Editas, hearing loss, reprogramming

April 17, 2022 / Professor Paul Knoepfler, Ph.D. / 3 Comments

We often don’t think of them that way but reproductive cells like sperm and egg are also relatives of stem cells, and it turns out that there are stem cells that make the reproductive cells too like sperm stem cells. Sperm and germ cell stem cells DNMT3A-dependent DNA methylation is required for spermatogonial stem cells […]

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Stem cell weekly reads: Jamie Thomson, Lamin B1, CRISPR

March 13, 2022 / Professor Paul Knoepfler, Ph.D. / Leave a Comment

The big news of the week was a $3.6 million settlement by a stem cell clinic, StemGenex, and one of its doctors in a class-action suit. I covered this StemGenex settlement and so did Michael Hiltzik of the LA Times and Paul Schloesser at Endpoints. I’d say this was good news for the stem cell field

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Stem cell reads: regeneration, 8C, MYC, CRISPR babies

February 27, 2022 / Professor Paul Knoepfler, Ph.D. / Leave a Comment

Another busy week including on the grant writing treadmill or should I say Mobius strip, but I’m always on the lookout for new reading and this week a lot popped up on regeneration. Also, a paper on healing and scarring. I regularly write about stem cell journals. For a long time, it seems like Cell Stem

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Weekly science reads: senescence, alt CRISPR, sickle cell update

January 9, 2022 / Professor Paul Knoepfler, Ph.D. / 1 Comment

victoria gray family crispr sickle cell b

Is 2022 going to be any better than 2020 or 2021 when it comes to things in general or for biomedical science? Related to the pandemic? It’s too soon to say but if I had to guess right now I’d venture an optimistic view that overall it’s going to be somewhat better by the end

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Weekly reads: R01 grant trends, DPPA4, adult human neurogenesis debate

November 21, 2021 / Professor Paul Knoepfler, Ph.D. / Leave a Comment

Great ideas and talented scientists are not enough as biomedical research needs funding and here in the U.S. that means having R01 grant success. The trends since 1995 are slowly heading the wrong way. The average age of getting your first R01 grant keeps getting older. There is also still a bit of a possible

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Human cloning is more likely now but would you take the big risks?

September 8, 2021 / Professor Paul Knoepfler, Ph.D. / 3 Comments

I’ve been following the research related to human cloning now for more than a decade. Is human cloning more possible at this point? How do we even define such cloning? Did you know there are two types? The goal of this post is to educate you and in the process answer such questions. What’s in

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Weekly reads: stem cells to gametes, no PRP benefit, WHO CRISPR, pubs

July 18, 2021 / Professor Paul Knoepfler, Ph.D. / 7 Comments

The paper of the week is from Science on making ovarian follicles and actual eggs from stem cells. It’s just in mice, but this line of work tends to stir people up. We’ll dive into that in a moment. But first some good news. We’re up to 146 subscribers on our stem cell YouTube channel

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Weekly reads: escape to New York, CRISPR baby patents, ISSCR guidelines, pubs

May 30, 2021 / Professor Paul Knoepfler, Ph.D. / 1 Comment

My to-read list this weekend includes a range of papers along with various news & media including a report of two US research groups aiming to get CRISPR baby patents. More on that below. At long last a trip + fun thing to do in NYC Last week I took my first trip in more

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When does a human embryo model become the real thing & other tough questions for a new field

May 19, 2021 / Professor Paul Knoepfler, Ph.D. / 2 Comments

A human embryo model is a laboratory-produced collection of living cells that has some key things in common with real human embryos. They are made from pluripotent stem cells, which include embryonic stem cells and induced pluripotent stem cells or iPS cells. This research is both exciting and ethically complicated, raising some difficult questions. Embryo

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Ukraine clinic plans to sell CRISPR enhancements: hair color, skin, & breast size

April 28, 2021 / Professor Paul Knoepfler, Ph.D. / 3 Comments

It was a couple of years back that researcher He Jiankui claimed he made three “CRISPR babies.” No one would think about doing any kind of rogue gene-editing again, right? Not even somatic gene edits. After all, as far as we know he’s in jail. We still don’t know the health risks that these three

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