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Probing Nature pub’s puzzling claim of brain cells globetrotting into prostate tumors

May 19, 2019 / Professor Paul Knoepfler, Ph.D. / 8 Comments

Mauffrey-Nature-Prostate-Neural-invasion-2019-Fig-3ce

A new Nature paper makes the striking claim that neural precursor cells of the brain migrate all the way to prostate tumors. Furthermore, the team led by Claire Magnon claims that these long-distance cellular travelers from the brain not only take up residence in the prostate but also strongly drive progression of the prostate cancer […]

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The future of California stem cell research & CIRM

May 15, 2019 / Professor Paul Knoepfler, Ph.D. / 1 Comment

The four words “California stem cell research” go nicely together and I hope they will continue to resonate in a special way to people around the world in the coming decade. We are at a crossroads for stem cell research in California as the original form of the California Stem Cell Agency (CIRM) winds down.

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Stem cell & other science weekend reads: arteries, diabetes, iffy metaphors, & more

May 10, 2019 / Professor Paul Knoepfler, Ph.D. / 1 Comment

weekend-reads-include-this-paper-from-Eric-Olsons-lab

What are your weekend reads? Many of us scientists read up on specific articles over the weekend that caught our eye during the last week or two. Here are some of my weekend reads plus some other stuff that just generally looked really interesting or unusual. The list includes both primary papers and news articles

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FTC returns half a mill to consumers of “deceptively marketed amniotic stem cell therapy”

May 7, 2019 / Professor Paul Knoepfler, Ph.D. / 4 Comments

There’s a lot of questionable “stem cell” injections these days involving purported amniotic stem cell or other perinatal (birth-related) material. Regulators are taking note including the FTC, which took some unprecedented action last year on this front. Now the FTC has announced that more than half a million $USD have been returned to consumers who

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Recommended recent stem cell, peds cancer & CRISPR reads

May 5, 2019 / Professor Paul Knoepfler, Ph.D.

Here are some articles that look especially interesting on stem cells, cancer, and CRISPR. I was just at the SNO meeting in SFO on childhood brain tumors so those are on my mind more. Childhood cerebellar tumours mirror conserved fetal transcriptional programs (Nature) Childhood brain tumors “think” they are building organds in fetuses. H3.3 K27M depletion

NY stem cell clinic pushes back on lawsuit by AG

May 1, 2019 / Professor Paul Knoepfler, Ph.D. / 8 Comments

Unproven stem cell clinics are facing a variety of lawsuits these days including two prominent cases filed by the FDA. There are widespread patient suits against clinics as well. In April we saw a new kind of suit in the form of the NY State Attorney General (AG) Letitia James filing against a Manhattan clinic.

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Weekend reads: reversing death of pig brain cells, brain-gut stem cell link, plant stem cells, & more

April 19, 2019 / Professor Paul Knoepfler, Ph.D. / 2 Comments

It’s been a cool week for stem cell and other associated kinds of research. In this post I have a series of links to a variety of interesting developments and papers. Gene therapy cures bubble boy infants. William Wan over at the WaPo on this good news. Nope, this wasn’t done with CRISPR, but rather

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My take as a biologist on US Stem Cell “natural” claim in federal court case endgame

April 16, 2019 / Professor Paul Knoepfler, Ph.D. / 12 Comments

It’s been less than a year since the FDA sued for a permanent injunction against a major stem cell clinic firm in Florida, but there has been much back and forth in court filings in the lawsuit between them and the firm, US Stem Cell. Now the case is with the judge. My prediction remains

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Stem cell good news: novel cancer work, new CA bills, Alzheimer’s, & more pubs

April 8, 2019 / Professor Paul Knoepfler, Ph.D. / 1 Comment

There’s nothing like stem cell good news and interesting publications to perk one up on a Monday. Enjoy. What recent papers have struck you as exciting? Novel stem cell-based cancer approaches (Part 1) It was exciting when Fate Therapeutics got the first induced pluripotent stem cell (IPSC) IND in the U.S. for their IPSC-derived natural killer cell

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Why NY AG suit against Manhattan stem cell clinic is such a big deal

April 7, 2019 / Professor Paul Knoepfler, Ph.D. / 7 Comments

The New York State Attorney General (AG) filed suit this week against a Manhattan stem cell clinic. It’s a landmark case. The defendants are Image Plastic Surgery, LLC, Park Avenue Stem Cell, and Joel B. Singer, M.D. The clinic markets adipose stem cell injections for a variety of health conditions. Park Avenue Stem had belonged

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