Recommended recent stem cell, peds cancer & CRISPR reads

dental stem cells
Collignon, et al, Stem Cells, 2019.

Here are some articles that look especially interesting on stem cells, cancer, and CRISPR. I was just at the SNO meeting in SFO on childhood brain tumors so those are on my mind more.

Childhood cerebellar tumours mirror conserved fetal transcriptional programs (Nature) Childhood brain tumors “think” they are building organds in fetuses.

H3.3 K27M depletion increases differentiation and extends latency of diffuse intrinsic pontine glioma growth in vivo. (Acta Neuropathologica) from Suzy Baker-led team.

H3K27M induces defective chromatin spread of PRC2-mediated repressive H3K27me2/me3 and is essential for glioma tumorigenesis. (Nature Communications) Majewski and Jabado team pub.

Daisy-chain gene drives for the alteration of local populations (PNAS). CRISPR gene drive goes unchained/chained.

A High-Throughput Platform to Identify Small-Molecule Inhibitors of CRISPR-Cas9 (Cell). Here come the anti-CRISPRs…more of them at least.

Mouse Wnt1‐CRE‐RosaTomato Dental Pulp Stem Cells Directly Contribute to the Calvarial Bone Regeneration Process (Stem Cells; see quirky graphical abstract). The promise of dental stem cells bolstered by more basic research.

Single-Cell Transcriptomics Uncovers Glial Progenitor Diversity and Cell Fate Determinants during Development and Gliomagenesis(Cell Stem Cell) Single-cell experiments tell us different things than studies on pools of millions of cells.

Modeling the Pathological Long-Range Regulatory Effects of Human Structural Variation with Patient-Specific hiPSCs (Cell Stem Cell) Another cool application via IPSCs.

A random, cool one on the galaxy of viruses in the ocean. Marine DNA Viral Macro- and Microdiversity from Pole to Pole (Cell)

Single-cell transcriptomic analysis of Alzheimer’s disease (Nature) More single-cell efforts.

New Effort to Require California Medical Board to Act on Snake Oil Stem Cell Clinics (news item from California Stem Cell Report on California bill on stem cell clinics).

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