What are the most important iPS cell papers so far? 1) Yamanaka’s first paper on mouse iPS cells. Revolutionary. Intriguing perspectives presented in day 1 of the iPS cell field. Interesting statements such as Myc is required. Also take a look at those other reprogramming factors that he tested…there’s a tremendous amount there, largely unexamined. […]
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Wait, what’s that taboo elephant doing in the IPS cell lab? You don’t see it? I’m starting a new series called “The Elephant in the Lab” where I discuss controversial laboratory topics that people are usually too afraid to publicly discuss. We are starting with iPS cells. (for a description and definition of iPS cells
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In the biomedical sciences we do a huge number of experiments on cells grown in culture including human cell lines. Where do all these cells come from? It’s an important question to ask. I got my first job in science as a fairly low level technician working at UCSD in La Jolla and my main
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Humans have big brains, right? In fact, they are downright supersized. But is that always such a good thing? As it turns out, no. Size matters, but bigger is not always better for brains at least. When I was in high school, my biology teacher had us do the requisite frog dissection and offered extra
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I confess: I have stem cells on the brain. Yeah, I probably have a few stem cells left in this old brain of mine, but that’s not what I mean….rather, I mean that I am really curious and excited about how stem cells do their jobs in our brains. More specifically, I wonder about things such
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Why do people have such a big brain compared to other animals? Vertebrate embryonic development is a highly conserved process, particularly in the earliest phases. (note: you may find this September 2020 post on regulation of bee brain size to be interesting.) A wide variety of vertebrate animals including humans start out with embryonic body plans
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Interestingly, the Komen Foundation appears open to funding human embryonic stem cell (hESC) research. The latest report from Science includes a quote from Komen that denies any changes in funding policy for research and suggests they have not ruled out funding such research: Contrary to circulating online reports, Komen has not “de-funded” any grantee based on human embryonic stem
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Federal funding of human embryonic stem cell (hESC) research is hanging by a tenuous thread at the moment. While currently legal, such funding is at the mercy of a legal case making its way through the courts. The latest stop for this case is a review by a 3-judge panel of the DC Circuit Court.
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I have in the past posted advice to new faculty and also top 10 advice list for the academic job hunt, but today I wanted to specifically talk about mentoring. Also, stay tuned for a special post later this week with an autobiographical section from Irv Weissman on his early career and who his key
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Podcast for Week of July 5 Topics –Stem Cell Tourism in the U.S. –CIRM –Article in the Hill by stem cell opponent –Stem cell hype on aging Podcast for Week of July 11 Topics: –two papers on stem cell-based tissue engineering and one on stem cell treatments for heart disease, –the Republican candidates for