Who is David Sinclair and why is he all over the media related to anti-aging efforts? This post is my effort to fact-check Sinclair’s statements in the context of the broader rejuvenation arena. In the process I also review his most recent paper from my view as a stem cell and cancer biologist interested in …
Review of new David Sinclair paper, supplements & anti-aging glitz Read More »
As we age a higher proportion of our cells end up in a senescent state, which has sparked interest in senolytic drugs and a broader area called senolytics research. The goal of today’s post is to give you an overview of this important area. How much data are there on efficacy or safety? Is the …
What are senolytics? Drugs, activator, supplements, risks Read More »
Today’s post is a review and fact check of stem cell supplements. What I found now in 2024 on stem cell pills and related supplements is concerning. As a stem cell biologist, I see risks here not only of wasting one’s money (no positive effect), but also of doing some harm. In certain cases, stem …
What is immune rejuvenation? How would that work and what would be the benefits? As we age, our immune systems can change in unhelpful and unhealthy ways. One such change is a drift in the balance of production of different kinds of immune cells. Such a shift can lead to too many of some immune …
A few dozen clinics in the US sell an unproven RNA therapy called supportive oligonucleotide therapy or SOT. The product comes from a Greek firm RGCC or Research Genetic Cancer Center, which also pre-tests patients’ gene expression to design the RNA product. Clinics marketing SOT in the US say it is intended to act by …
Anti-aging might already be the big regenerative medicine story of 2024 and it’s only early March. Anti-aging hype going to the dogs? One of my 20 stem cell and regenerative medicine predictions for 2024 was that longevity would continue to make big news including in some not-so-great ways. In just over two months there has …
Every year I give out The Screamers Science Hype Award. The point of The Screamers is to raise awareness about science hype and catalyze new ways to combat it. In that spirit, I award what I see as the most extreme examples of science hype. Sometimes in addition to the one main winner, I give “honorable” …
2023 The Screamers Science Hype Award goes to anti-aging media coverage Read More »
The FDA has a unique mechanism called RMAT or regenerative medicine advanced therapy designation. It’s intended to move investigational regenerative therapies forward more effectively. RMAT data I recently updated The Niche RMAT list and it has jumped to 85. The FDA has approved many new RMATs this year. The data on how many applications the FDA …
Can you paradoxically kill yourself early by trying to cheat Death? For example, die through risky anti-aging approaches? The question came to mind because such longevity efforts have become more extreme. They also get more hype in the media. I’ve been following the anti-aging space mainly because many interventions involve risky stem cell injections. Those …
Can trying to cheat death paradoxically kill you sooner? Read More »
We all know people who seem far younger than their age, which feeds into the idea of biological age. It’s often in the news these days and all over social media. Some people who are fighting high-profile battles with aging are also doing something I call “health flexing.” I also called these folks by another …
Biological age, health flexing, & stabs at rejuvenation Read More »