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Exciting CRISPR-powered “gene drive” also has scientists deeply concerned

August 12, 2015 / Professor Paul Knoepfler, Ph.D.

Scientists studying genetics are both excited and worried about a powerful, new technology called “gene drive“. Some have been raising serious concerns about gene drive and in certain cases calling for proactive regulation, which is unusual in science. This method is so powerful because it is designed to induce genetic changes in an entire population […]

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Steven Pinker interview: case against bioethocrats & CRISPR germline ban

August 10, 2015 / Professor Paul Knoepfler, Ph.D. / 15 Comments

CRISPR-Cas9 gene editing technology is red-hot right now and I’ve been doing interviews with various thought leaders on it, which today includes Steven Pinker. This technology has great power for research in the lab and there are hypothetical transformative clinical applications of CRISPR too. The latter efforts could include experimental attempts at reversal of disease-causing

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Elephant in the lab series: common science excuses

August 9, 2015 / Professor Paul Knoepfler, Ph.D. / 6 Comments

In this Elephant in the lab series we discuss the most taboo topics in science. Past Elephant in the lab examples include such pieces as the following: Dirty dozen easy steps to killing a paper Scientist’s guide to insulting other scientists Followed by insults 2.0 that was a post including even nastier science insults Top 10 reasons

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Michael Cea ISSCR chat with Jeanne Loring on stem cell field

August 5, 2015 / Professor Paul Knoepfler, Ph.D. / 3 Comments

ISSCR Chat By Michael Cea Jeanne Loring of the Scripps Research Institute in La Jolla, California kindly sat down with me at the ISSCR annual meeting for a broad discussion of her history, views on the field and developments in the science. I found Jeanne a refreshing character, as I did a number of others I was

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Fantastic organoid voyage: views from inside organoids

July 30, 2015 / Professor Paul Knoepfler, Ph.D.

The classic sci-fi movie Fantastic Voyage keeps coming to mind for me as I see and do research involving organoids. In it, the heroes travel inside of the human body in a craft, observing all kinds of awesome biology in an up close and personal kind of way on route into the brain with the goal

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Nita Farahany Interview on Human Germline Modification: Defining A Road Forward

July 28, 2015 / Professor Paul Knoepfler, Ph.D. / 1 Comment

The topic of heritable human genetic modification has been heating up recently. Prominent scientists, ethicists, and legal scholars have being weighing in, and there is a range of attitudes. Some favor a complete, moratorium including even lab work, while on the other end of the spectrum there are those who have a more liberal perspective. Many

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More info on Bart Starr unproven clinic stem cell treatment

July 22, 2015 / Professor Paul Knoepfler, Ph.D. / 10 Comments

Both current and former professional sports stars are lining up to get stem cell “treatments” of various kinds for all sorts of injuries and medical conditions including now Bart Starr. The aging stars who have received stem cell interventions include former San Francisco 49ers quarterback John Brodie (age 79) and more recently hockey legend, Gordie

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What countries are ‘punching above their weight’ in stem cell space?

July 21, 2015 / Heather Main / 5 Comments

What countries are doing disproportionately well given their size on their stem cell research? When reading through the ISSCR 2015 program you can understand why everyone wants to go to the US for their postdoc as it seems like most of the work being presented is US-based. In fact, this is more than true with

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Stem cell mistaken identity: who are you?

July 19, 2015 / Professor Paul Knoepfler, Ph.D. / 1 Comment

One of the biggest issues in the world of cellular medicine and also in cellular research is one of mistaken identity. I’m talking about scientists, doctors, or others thinking that their cells are one type (say type X) when in reality the cells are something else (say type Y). Or maybe the cells are some mixture

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Masayo Takahashi (高橋政代) on IPSC Trial for Vision

July 7, 2015 / Professor Paul Knoepfler, Ph.D. / 9 Comments

Masayo Takahashi (高橋政代) on IPSC Trial for Macular Degeneration By Michael Cea Stem Cell Analyst & Advocate (editor’s note: piece was originally posted on Michael’s blog here; follow Michael on Twitter @msemporda) Masayo Takahashi interview Having followed closely the developments in programs using pluripotent based therapeutics I was fortunate during ISSCR2015 to have the opportunity to

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