Search Results for: us stem cell

Weekly reads: stem cell good news, bad news on sickle cell, MS, IPSCs

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victoria gray family crispr sickle cell b

Let’s start with some stem cell good news on evolving approaches to treat sickle cell disease involving stem cells. Then on another related front things were more concerning. Stem cell good news on sickle cell disease, a complication Sickle Cell Disease News reports Adding Briquilimab Boosts Success of Sickle Cell Stem Cell Transplant. This is a […]

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Wrinkles in pitch of celeb fav Augustinus Bader cream

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Kris Jenner, Jennifer Aniston, Augustinus Bader cream

Many celebs seem to be into cosmetics called Augustinus Bader cream products that claim to do something related to stem cells. The brand is wildly expensive. What’s this all about? Augustinus Bader is both a person and a line of cosmetic products. The goal of today’s post is to fact-check the claims and products of the Augustinus

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Fact-checking stem cell stroke therapy: hope but not there yet

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Stem cell stroke therapy

Stem cell stroke therapy research has generated buzz over the years. The goal of today’s post is to fact-check claims about supposed stem cell stroke therapies and educate readers on where clinical research stands. There is some real hope here in the long run, but things have been greatly exaggerated at times. Some clinics are

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Weekend reads: WaPo blows it on COVID, paper-mill detector, adult pluripotent stem cells

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"Hofstenia miamia, three-banded panther worms. Credit: Mansi Srivastava and Kathleen Mazza-Curll"

Imagine writing or editing an article for the WaPo about risky, unproven medical interventions for COVID that desperate patients might consider. Then you link directly to the websites selling this stuff in your article. What the heck? WaPo links to risky long COVID “treatments” By linking, you not only are driving customers to these firms,

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Weekly reads: Gamida Cell, Siddhartha Mukherjee, CRISPR in viruses

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Abigail L. Jenkins, Gamida Cell

Hematopoietic stem cells have many clinical applications and a company called Gamida Cell has an interesting product in this area called Omidubicel that may have several applications.  I’m going to start the weekly reads with news there. Gamida Cell and the FDA A recent piece discussed how Omidubicel is progressing with the FDA. FDA extends

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Stem cells & the philosopher’s stone, P53, thyroid organoids

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philosopher's stone

I hadn’t remembered the history of the philosopher’s stone until reading a new review article about stem cells and aging. Here’s the article. Is the philosopher’s stone to rejuvenate blood stem cells an epigenetic regulator? Nature Aging. This preview kind of piece discusses how inhibiting a specific factor called PHF6 can “rejuvenate” HSCs in mice.

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Clinical utility & examples of unipotent vs. multipotent stem cells

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mesenchymal cells

What are examples of unipotent and multipotent stem cells? More broadly, stem cells have the ability to do two key things. They can make more of themselves through a process called self-renewal. Also, they have the ability to differentiate into other cell types. This latter property is called potency. Taken together this means by definition

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Weekly reads: death in CRISPR trial, sickle cell, nose picking & dementia, epilepsy

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CRISPR gene editing

As both a scientist who works on stem cells, cancer, and CRISPR, and a research advocate I’ve been fortunate to meet many patient advocates over the years. Some have been participants in clinical trials themselves. Benefits & risks of clinical trial participation It is very sobering to find out that a clinical trial participant has

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Review of ExoFlo paper used to push Direct Biologics IND inside FDA finds red flags

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ExoFlo from Direct Biologics

I wrote recently about how political pressure on FDA Commissioner Stephen Hahn in 2020 may have helped the Texas firm Direct Biologics move their product ExoFlo forward inside the agency. Today I analyze the ExoFlo Phase I clinical trial paper used in that push on Hahn to get the firm the IND for a Phase II

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