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Weekly reads: CRISPR’d marsupial, outpatient recovery post stem cell transplants, Parkinson’s, pubs

CRISPR'd baby opossums.

This edition of The Niche weekly reads has a bit more good news than usual including on stem cell transplants. It’s nice to see positive developments like some recipients of hematopoietic stem cell transplants being able to stay at home afterwards. Also, a reminder. You have until July 31 to enter our stem cell video …

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Weekly reads: stem cells to gametes, no PRP benefit, WHO CRISPR, pubs

making human eggs from stem cells

The paper of the week is from Science on making ovarian follicles and actual eggs from stem cells. It’s just in mice, but this line of work tends to stir people up. We’ll dive into that in a moment. But first some good news. We’re up to 146 subscribers on our stem cell YouTube channel …

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Weekly reads: stem cells vs. viruses, prostate cancer, apoptotic cell niche function, more

Morinaga et al Nature 2021 Stem cells and hair loss

The paper of the week is An isoform of Dicer protects mammalian stem cells against multiple RNA viruses published in Science. The take-home from the abstract is that the data, “demonstrate that mammalian stem cells can protect themselves from some RNA viruses by expressing an alternatively spliced isoform of the enzyme Dicer called aviD, which potentiates …

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Weekly reads: life extension & BioViva, clinics & anti-vax, axolotls, systemic CRISPR

BioViva CEO Liz Parrish in YouTube video.

Let’s start off today’s recommended reads with the topic of life extension. No controversy there, right? This comes to mind because of a new preprint from BioViva, Liz Parrish, and George Church. I’m hoping to cover this on our Stem Cell Channel on YouTube.  Gene therapy and life extension research The preprint is entitled, “New …

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Weekly reads: cancer stem cells & other pubs plus a puzzler

kyu yum nature cancer stem cells niche

Cancer stem cells are one of the most interesting areas of research, intersecting the stem cell and cancer fields. Today’s weekly reads post highlights some new cancer stem cell articles along with some other interesting papers. I also note a recent weak stem cell clinical trial paper that is not a recommended read but is …

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Weekly reads: escape to New York, CRISPR baby patents, ISSCR guidelines, pubs

the high line in manhattan

My to-read list this weekend includes a range of papers along with various news & media including a report of two US research groups aiming to get CRISPR baby patents. More on that below. At long last a trip + fun thing to do in NYC Last week I took my first trip in more …

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Weekly reads: Orchard punts on life-saving SCID trial, cardioids with cavities, more

cardioids stem cells

Sometimes things in the stem cell world get complicated and this week is no exception with news of Orchard Therapeutics dropping a seemingly life-saving clinical trial. There are hundreds of kids who could possibly benefit. Rotten apple decision from Orchard Therapeutics From David Jensen at California Stem Cell Report we have something of a scoop: …

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Weekly reads: court case, cancer stem cells, skin, pluripotency, & more

chen et al fig 1e nat comm 2021 phc1

This was a busy week for me working on a grant due Friday and a bunch of other stuff including happily analyzing a bunch of data, but there were tons of interesting papers recently including on pluripotency. California stem cell clinic court case on in the background Along the way this week I was occasionally …

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Weekly reads: oncodevelopmental factors, iPSC cancer vaccine, more

stem cell vaccine paper ouyang et al

One of my main research interests is in oncodevelopmental factors. These include factors that are important both for normal stem cell biology and development as well as driving cancer when misregulated. One example includes the MYC family of proto-oncogenes. When I was a postdoc I got especially interested in trying to understand the normal role …

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Weekly reads: Stem cells for vision loss & recommended pubs

stem cells for vision loss ribeiro et al

I’m going to start off today’s recommended reads post with some stem cells for vision developments. I had some fun the last 2 weeks as people sent in their entries for our $100 stem cell picture contest. I’ll announce the winner this week. It’s going to be hard to choose given the great entries. Stem …

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