January 22, 2021

The Niche

Trusted stem cell blog & resources

Month: July 2014

4 min read

Many of this The Niche‘s readers ask about what my own lab’s research. What is the focus of the research of the Knoepfler Lab? You can go check out our lab website, but I thought it might be time to blog about what we are all about as a lab and what we have been up to most recently. I am fortunate to have an exceptional team of researchers in my lab. Our mission is to advance knowledge toward two main goals: (1) the …Read More

3 min read

Stem cell-based Regenerative Medicine has huge power for good in the clinic and at the same time great potential for economic development. Those two things go hand in hand. As I argued in my stem cell book, biotech commercialization of stem cells is not a bad thing, but rather if it is done responsibly it is a good, necessary part of advancing therapies to help patients. From an economic perspective  stem cell-based Regenerative Medicine is a new, exciting brand. Update, now 6 years later, …Read More

1 min read

What have been some recent stem cell and/or regenerative medicine papers that are worth some extra thought and reading? There have been some cool ones. Note, for fun you can fast forward ahead to 2020 to see some of the recommended reads there. There was of course the very important Mitalipov group paper comparing NT hESCs to IVF hESCs and hIPSCs. See my review here. There was a great paper on the role of HDACs in mESCs. A paper reporting making endothelial and hematopoietic cells …Read More

2 min read

StemCells, Inc. is one of those stem cell-related biotech companies that we in the field hope will become a big success and help many patients in the future via stem cell technology. There are a lot of obstacles facing such companies. Some are privately held, while others such as StemCells, Inc. are publicly traded (stock symbol STEM). Unfortunately, StemCells, Inc. has had to face two rather serious problems in the last few weeks. First, former CIRM President Alan Trounson joined the leadership of StemCells, Inc. only days …Read More

4 min read

What might be some natural stem cell boosts? How might we all increase the number or helpful activities of our own stem cells? If possible isn’t that a better, simpler, & safer idea than getting a transplant of stem cells? Think of it as preventative medicine via stem cells. Note that this post was updated in May 2020. It’s not a sure thing by any means. And, yeah, it is not as simple as asking for a free or super boost in your Jamba …Read More

3 min read

Is there real promise of stem cells for autism? At this point the jury remains out on that question, but a growing number of kids are nonetheless getting such “treatments” at for-profit dubious clinics. Academic clinical researchers are interested in this area as well. Still, the potential use of stem cells to treat autism is a highly controversial area even in a clinical trial setting. Today it was announced in a piece on the website of the Simons Foundation Autism Research Initiative that a dramatically …Read More

2 min read

Want $100 to buy anything you want on Amazon and have a passion for stem cells? Then you are the ideal person to enter this blog’s new stem cell video contest. I’m looking for a video that will really make people think and perhaps learn something new. Outside the box thinking. Novel information. Humor. A cool new resource. A commentary or new view on things. All these would be good for this contest. A bit controversial is a good attribute too, but outright offensive …Read More

1 min read

I’ve always got stem cells on the brain. What’s on your mind about stem cells? There’s a ton going on so what specifically has got your attention? What are you thinking about? What has you excited? Depressed? Angry? Hopeful? Headlines from the last few weeks: Nuclear transfer ES cells compared to iPS cells Trounson moves from CIRM and joins board of StemCells, Inc. See this striking follow up to this story. STAP cell retractions Angel Di Maria, Stem Cells, and the World Cup Patient …Read More

2 min read

I have been corresponding now and then with Dr. Teru Wakayama about the ongoing STAP situation. He asked me to pass along the following message from him for clarification on the STAP Nature paper retraction and the origin of the STAP stem cells (STAP-SC). I would like to take this opportunity to explain the reason for certain differences between the retraction statement in the published paper version of Nature Magazine and the online version of the STAP paper retraction, specifically related to reason No. (5) which …Read More

3 min read

Clare Wilson over at the NewScientist has reported the case of a woman given an experimental stem cell treatment in Portugal for a spinal cord injury who later developed a strange tumor consisting of nose tissue. I highly recommend going over to that site and reading her excellent article. What’s the deal with this case? The woman was treated with nasal stem cells eight years earlier. Her condition did not improve and now eight years later the tumor was removed in the US from her spine. The …Read More