June 3, 2020

The Niche

Knoepfler lab stem cell blog

Month: July 2014

4 min read

Many of this The Niche‘s readers ask about what my own lab’s research. What is the focus of the research of the Knoepfler Lab? You can go check out our lab website, but I thought it might be time to blog about what we are all about as a lab and what we have been up to most recently. I am fortunate to have an exceptional team of researchers in my lab. Our mission is to advance knowledge toward two main goals: (1) the …Read More

3 min read

Stem cell-based Regenerative Medicine has huge power for good in the clinic and at the same time great potential for economic development. Those two things go hand in hand. As I argued in my stem cell book, biotech commercialization of stem cells is not a bad thing, but rather if it is done responsibly it is a good, necessary part of advancing therapies to help patients. From an economic perspective  stem cell-based Regenerative Medicine is a new, exciting brand. It’s a brand, but a …Read More

1 min read

What have been some recent stem cell and/or regenerative medicine papers that are worth some extra thought and reading? There have been some cool ones. There was of course the very important Mitalipov group paper comparing NT hESCs to IVF hESCs and hIPSCs. See my review here. There was a great paper on the role of HDACs in mESCs. A paper reporting making endothelial and hematopoietic cells from pluripotent stem cells with a combination of GATA2 and other individual transcription factors. In vivo reprogramming in …Read More

2 min read

StemCells, Inc. is one of those stem cell-related biotech companies that we in the field hope will become a big success and help many patients in the future via stem cell technology. There are a lot of obstacles facing such companies. Some are privately held, while others such as StemCells, Inc. are publicly traded (stock symbol STEM). Unfortunately, StemCells, Inc. has had to face two rather serious problems in the last few weeks. First, former CIRM President Alan Trounson joined the leadership of StemCells, Inc. only days …Read More

4 min read

What might be some natural stem cell boosts? How might we all increase the number or helpful activities of our own stem cells? If possible isn’t that a better, simpler, & safer idea than getting a transplant of stem cells? Think of it as preventative medicine via stem cells. Note that this post was updated in May 2020. It’s not a sure thing by any means. And, yeah, it is not as simple as asking for a free or super boost in your Jamba …Read More

3 min read

Can stem cells be used to treat autism? At this point the jury remains out on that question, but a growing number of kids are nonetheless getting such “treatments” at for-profit dubious clinics. Academic clinical researchers are interested in this area as well. Still, the potential use of stem cells to treat autism is a highly controversial area even in a clinical trial setting. Today it was announced in a piece on the website of the Simons Foundation Autism Research Initiative that a dramatically larger …Read More