Sometimes things in the stem cell world get complicated and this week is no exception with news of Orchard Therapeutics dropping a seemingly life-saving clinical trial. There are hundreds of kids who could possibly benefit.
Rotten apple decision from Orchard Therapeutics
From David Jensen at California Stem Cell Report we have something of a scoop: ‘Wicked’ Problems, Orchard Therapeutics and Bubble Babies: A California Stem Cell Story.
Orchard Therapeutics cited “business reasons” for terminating its seemingly successful stem cell clinical trial for SCID.
It feels to me like a tragedy to see a biotech stop a trial that seems to have already saved lives and could save many more.
What about the tens of millions of dollars that CIRM invested here? Should Orchard have to pay that back? Jensen has a follow-up piece at Capitol Weekly with more information about CIRM’s perspectives on the decision by Orchard Therapeutics.
The more encouraging news is that CIRM seems very devoted to continuing this work clinically. The hope is that another biotech will pick up the trial and Orchard will facilitate that.
Here’s a newer update from David Jensen.
Heart self-organization from stem cells
Some more recommended papers: T cells and more
- Generation of hypoimmunogenic T cells from genetically engineered allogeneic human induced pluripotent stem cells, Nature Biomedical Engineering.
- Human delta like 1-expressing human mesenchymal stromal cells promote human T cell development and antigen-specific response in humanized NOD/SCID/IL-2R $$\upgamma $$ γ null (NSG) mice, Scientific Reports
- MeCP2 controls neural stem cell fate specification through miR-199a-mediated inhibition of BMP-Smad signaling, Cell Reports
- SFRP2 induces a mesenchymal subtype transition by suppression of SOX2 in glioblastoma, Oncogene
- Study of inherited thrombocytopenia resulting from mutations in ETV6 or RUNX1 using a human pluripotent stem cell model, Stem Cell Reports
- Acute myeloid leukemia-induced functional inhibition of healthy CD34+ hematopoietic stem and progenitor cells, Stem Cells.