Search Results for: "clonal expansion"

Weekly reads: clonal expansion, Golden Retriever cancer, FTC hits genetics firm on testi-phony-als

clonal selection

Let’s start this week’s digest with a discussion of clonal expansion and mutations during cell and gene therapy development. Here’s the article that brought this to mind. Sickle cell gene therapy process may cause cancer-linked mutations in blood stem cells, Fierce Biotech. Clonal expansion This is a story about a non-CRISPR gene therapy using a …

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Weekly reads: immune rejuvenation, Cryo-Cell spin-off, stem cell patches, direct reprogramming

Irv Weissman, immune rejuvenation

What is immune rejuvenation? How would that work and what would be the benefits? As we age, our immune systems can change in unhelpful and unhealthy ways. One such change is a drift in the balance of production of different kinds of immune cells. Such a shift can lead to too many of some immune …

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Some CAR-T may very rarely cause new cancers

CAR-T, CAR-T cancer

The FDA issued a statement this week that there have been reports of new cases of blood cancer after patients received CAR-T therapies. The FDA specifically mentions T cell malignancies. New cancers in rare cases? In the announcement, FDA Investigating Serious Risk of T-cell Malignancy Following BCMA-Directed or CD19-Directed Autologous Chimeric Antigen Receptor (CAR) T cell …

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Weekly reads: stem cell activator, sleep & stem cells, clonal hematopoiesis

stem cells macrophages, stem cell activator

When people find out that I’m a stem cell researcher, a common question is whether there’s something they can take that is a stem cell activator. I’ve written before about whether there are stem cell boosts that one can do to try to be healthier. Sleep, stem cell activator and clonality Mostly when I bring …

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Recommended reads: stem cells for ALS treatment trial, epigenome editing, astronaut mutations, ‘3-person embryo’ DNA

stem cells for ALS treatment

A new stem cells for ALS treatment trial represents a big step forward. It’s early days still but this trial shows feasibility and provides a helpful foundation for moving forward. It also highlights challenges. The work is from a team led by Clive Svendsen. Stem cells for ALS treatment trial Here’s the study. Transplantation of …

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Human cloning is more likely now but would you take the big risks?

human cloning

I’ve been following the research related to human cloning now for more than a decade. Is human cloning more possible at this point? How do we even define such cloning? Did you know there are two types? The goal of this post is to educate you and in the process answer such questions. What’s in …

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