July 15, 2020

The Niche

Knoepfler lab stem cell blog

Search Results for: senolytics

3 min read

Over the weekends I try to catch up on more diverse reading and sometimes come up with a list of stuff I want to get to during this time, but I also put together weekend reads usually on Fridays as a kind of TGIF on The Niche for the wider audience here. So here’s the weekend reads for this Friday the 13th including some wacky stuff at the end. Anti-Aging efforts got some play in the media including this LA Times piece. Here’s the …Read More

3 min read

My weekly roundups of biomedical news tend to focus on stem cells, but I read more broadly so it’s not just stem cells but also CAR-T cells and a lot more this week. CAR-T cells as senolytics? A team led by Scott Lowe has a new intriguing paper in Nature on using CAR-T cells to target senescent cells. The paper is entitled, “Senolytic CAR T cells reverse senescence-associated pathologies”. The core idea here is that CAR-T cells can be used to get rid of …Read More

4 min read

Historically, the main route of proposed healing via stem cell therapy was cell replacement. In this way of thinking the transplanted cells engrafted (took up home) in the patient’s tissue and replaced dead or diseased cells. However, interest continues to grow in other possible modes of healing by stem cells that don’t rely on cell replacement. In today’s post I cover 4 other possible mechanisms for stem cell therapy to aid health. Secreted factors An alternative, not mutually exclusive model to cell replacement is …Read More