CRISPR

Weekend reads: stem cells, CRISPR, glioma, stroke, RTT & more

Venkatesh-et-al.-Nature-2019-Fig-2e

Every so often I realize I’ve accumulated a bunch of tabs on my browsers of things I need to dive into as time permits, which sometimes translates into a collection of recommended reads here on The Niche. Here are some recommended recent reads in the stem cell/regenerative medicine field and childhood cancer space. It includes […]

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ViaCyte Q&A: CRISPR Tx quick progress, ongoing diabetes trial, & more

ViaCyte-CyT49-PSC

ViaCyte is one of the most exciting stem cell and regenerative medicine biotech companies so I like to try to check in with them regularly. Today’s post is my new interview with ViaCyte leader Paul Laikind on recent developments. We had a great chat about the science and how things are looking upbeat for the

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Good news science digest: HIV, brain, CRISPR, cats vs. dogs, space, & more

brain-lymphatics-l

Every now and then I collect a bunch of recent science good news that I’ve come across. Here are some past ‘good news’ posts. Today’s post includes such a recent collection and some funny stuff too at the end. Enjoy! BTW, science is not necessarily all about stem cells, right? Talk about good news. 1,000th

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CRISPR baby moratorium grows likely with rising tide of support including from biotech

CRISPR-gene-edit-vs-mutation-1

Trying to make a CRISPR baby any time soon would be a really bad idea. How bad? Last December 3rd I penned a piece for STAT News arguing for a moratorium on the heritable use of CRISPR in humans. This potential future, radical application of “gene editing” is now often colloquially referred to as “CRISPR

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How to Build a Dragon or Die Trying: check out new book with my daughter Julie

How-to-Build-a-Dragon-or-Die-Trying

My daughter Julie and I have written a book together entitled,  “How to Build a Dragon or Die Trying, A satirical look at cutting edge science.” The book will be out sometime in June most likely. This is a very different kind of book than my first two, Stem Cells: An Insider’s Guide and GMO

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Counterpoints to Lovell-Badge & Daley’s CRISPR baby rationales

CRISPR-baby

Two prominent scientists, Robin Lovell-Badge and George Daley, have been amongst the most outspoken proponents of leaving the door open to heritable human genetic modification via CRISPR. While they each have articulated their reasons in somewhat different ways at times, their core reasons arguing in favor of future heritable CRISPR appear largely the same. In

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When the state & ‘rogue’ scientists collide: case of China & CRISPR baby guy He Jiankui (贺建奎)

He-Jiankui-贺建奎

What happens next to He Jiankui (贺建奎) or as some people now refer to him, the “CRISPR baby guy”? China has a challenging situation to resolve here, but such conflicts between scientists and governments have happened regularly in history. When scientists go “rogue” (i.e. don’t conform to norms or ethical standards in an extreme way or

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Who is He Jiankui’s mentor Michael Deem & is he trying to edit himself out of CRISPR baby project?

Michael-Deem

Who is Michael Deem and what was his role in his former student He Jiankui’s purported production of twin CRISPR’d babies? Is Deem now trying to edit himself out of the project? He Jiankui relied on help from many people and Deem was reportedly a part of that team. Members of He’s own research team helped

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Context for my Nature piece on redefining “gene edit” to be more precise

CRISPR-gene-edit-vs-mutation-1

When I say “gene edit” or “genome editing”, what’s the first thing that pops in your mind? It will depend on who you are. For many lay people until a few weeks ago when the world heard about He Jiankui‘s claim of CRISPR’d babies they may not have had anything pop in their heads when

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Mixed messages on CRISPR babies from National Academies versus their experts: a look at new Science piece

National-Academy-CRISPR-Baby-article

Three national academy leaders have a new opinion piece in Science on what the community needs to do next regarding human germline editing now that we are most likely in the CRISPR babies era. Some of us have been wondering what the Academies and their empowered experts really think about this issue and what they

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