Vision

Vision research and vision loss

New suit for vision loss against Cell Surgical Network clinic

Dr. Alvaro Skupin listing on the Cell Surgical Network website. Screenshot.

A stem cell clinic in the Cell Surgical Network chain has just been sued allegedly for causing vision loss in a patient. By my count, across the U.S. this makes at least 5 patients who have said they were either totally blinded or had some major vision loss after getting stem cells injected into their …

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Weekly reads: vision, MyoD, liver regen, more

fish-eyes-from-stem-cells, stem cells for vision

I love stem cell research but experiments that have practical possible future applications in medicine like for vision loss are especially interesting to me. On the other hand basic research on core transcription factor mechanisms like by MyoD also really grab me. We cover some of this stuff and other ground in today’s recommended reads. …

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A look at “eyes on the brain organoids” Cell Stem Cell paper

brain organoids eyes

Sometimes a paper really catches your eye like a new Cell Stem Cell pub reporting eye-like structures grown on brain organoids. The paper is Human brain organoids assemble functionally integrated bilateral optic vesicles. Let’s take a quick look at this paper, its context, and the potential big-picture implications. Brain organoids with “eyes”? At first glance, …

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Weekly reads: Stem cells for vision loss & recommended pubs

stem cells for vision loss ribeiro et al

I’m going to start off today’s recommended reads post with some stem cells for vision developments. I had some fun the last 2 weeks as people sent in their entries for our $100 stem cell picture contest. I’ll announce the winner this week. It’s going to be hard to choose given the great entries. Stem …

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Recommended regenerative medicine reads: COVID-19 updates, Cornea Fix, Pubs

2019nCoV-NP-cardio-myocytes

Another week and more great papers and interesting news in the regenerative medicine sphere including COVID-19 updates, stem cells for vision, and more. Rebuilding Corneas With Stem Cells Stem cell-based regenerative medicine arguably has shown the most promise for vision loss. A PR from Massachusetts Eye and Ear says: Doctors rebuild damaged corneas using patients’ …

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Groundbreaking Organoid Vision Clinical Study: Takahashi Q&A

Mandai-et-al-Stem-Cell-Reports-2017

Organoid based clinical trials are still rare and a Clinicaltrials.gov search for such organoid work largely brings up in vitro studies. A new clinical study in Japan where organoid material will actually be transplanted into patients is causing a lot of excitement. Organoid clinical trial Masayo Takahashi (高橋 政代) is a pioneer in stem cell-based …

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1st autologous IPS cell clinical trial for vision loss in the US

Fig.-4a-Schaub-et-al-JCI-2019-

The NIH announced the launch of the 1st autologous induced pluripotent stem (IPS) cell trial for vision loss in the U.S., focused on macular degeneration. The protocol is based on a solid foundation of pre-clinical animal studies: “Researchers at the National Eye Institute (NEI) are launching a clinical trial to test the safety of a …

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MD Stem Cells purported Right To Try program

Steven-Levy-Jeffrey-Weiss, SCOTS trial

I’ve been concerned about a stem cell group called MD Stem Cells for many years. Now it comes under more scrutiny from a new must-read piece by Donna Young over at S&P Global. Young’s article reports a puzzling, purported right-to-try (RTT) program that MD Stem Cells appears to working on with Richard Garr. Note that …

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Recent stem cell news: vision, brain organoids, & lab meat

human-corneal-anatomy2

365 days a year, 24 hours a day stem cells are growing in labs around the world, providing a never-ending stream of data and products, with real hope, good news, and lots of surprises. You can see some past examples of good news in the stem cell and regenerative medicine field highlighted on The Niche here. …

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Possible safety concerns from new stem cell, RPE vision loss study report

Figure-1-Mehat-et-al.-AAO-Journal-2018-810x1024-1

With stem cells for vision loss, first we want to be sure a treatment won’t make things worse. Several teams around the globe are rigorously studying stem cell-based approaches to vision loss via regulatory-compliant studies including for macular degeneration with some results cautiously upbeat on safety from early phase analyses, but data from a new study on …

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