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Mitalipov Nature pub review: IPSC & SCNT for mitochondrial disease

July 15, 2015 February 1, 2021 / By Professor Paul Knoepfler, Ph.D. / 6 Comments

In a new, thought-provoking paper today in Nature, Shoukhrat Mitalipov and a multi-institutional team report a significant advance toward potential novel ways to treat mitochondrial diseases. What are these illnesses? Mitochondrial diseases are rare, but devastating disorders caused by genetic mutations. Today they are largely impossible to treat in meaningful ways other than palliative care. Some …

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Insider Trends on Stem Cells to Look Out for at ISSCR 2015 Stockholm

June 24, 2015 December 22, 2023 / By Professor Paul Knoepfler, Ph.D. / 3 Comments

The annual ISSCR meeting has started in Stockholm. This is always a great annual meeting both for the science and for connecting with people including new friends and colleagues as well as old friends. Another element to the meeting is the insider conversations in the halls, restaurants, and bars that tell a behind the scenes …

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Monday, March 2: My Reddit AMA on 3-Person IVF – Mitochondrial Transfer

February 27, 2015 February 1, 2021 / By Professor Paul Knoepfler, Ph.D.

On Monday, I’ll be doing another Reddit AMA, this time on 3-person IVF also known as 3-parent IVF, mitochondrial transfer, 3-parent babies, etc. You can see the upcoming AMAs including mine listed in the right sidebar here. Mine will start at 10AM PST/1PM EST. I hope to discuss with a wide audience all the key …

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Super Science Weekend Reading

February 21, 2015 February 1, 2021 / By Professor Paul Knoepfler, Ph.D.

Here’s some thought-provoking weekend reading. ALEXEY. CLINICAL CELL PROCESSING NEWS – PART 1, 2015 BIOPOLITICAL TIMES. MITOCHONDRIAL MISSION CREEP AND THE CLONING CONNECTION CALIFORNIA STEM CELL REPORT. CALIFORNIA’S BOB KLEIN PROPOSES $100 BILLION, INTERNATIONAL STEM CELL/GENOMICS VENTURE CARL ZIMMER. A NEW THEORY ON HOW NEANDERTHAL DNA SPREAD IN ASIA DN LEE. YOU SHOULD KNOW: MICHELLE HUNTER AND EXPLORING NEUROSCIENCE THROUGH …

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Austen Heinz of Cambrian Genomics Interview: GMO creatures & people

January 14, 2015 February 1, 2021 / By Professor Paul Knoepfler, Ph.D. / 5 Comments

What’s Cambrian Genomics? With rapid advances in genomics, gene editing, and methods to reproduce life in the lab such as cloning, today creating genetically modified organisms (GMOs) has never been easier. While there have been of course loads of discussions of GMOs in the past, we are entering a new era of what one might …

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Positive Stem Cell Developments in 2014

December 24, 2014 December 22, 2023 / By Professor Paul Knoepfler, Ph.D. / 2 Comments

A lot has happened in 2014 in the stem cell and regenerative medicine field and so much of it has been good news so let’s focus on the positive. These positive developments are often the result of many years of creative, hard work by amazing teams of researchers. Here is my top 10 list of …

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Stem Cell Story of The Year 2014 Poll

November 30, 2014 February 1, 2021 / By Professor Paul Knoepfler, Ph.D. / 1 Comment

What was the biggest stem cell story of the year for 2014? Every year I post my view on what was the biggest stem cell event of the year. You can see picks for past years including human therapeutic cloning (production of nuclear transfer human ES cells) for 2013, the strangest stem cell story of …

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Dieter Egli Interview: NT-ES cells, IPSC, Mitochondrial Transfer, & More

November 17, 2014 February 1, 2021 / By Professor Paul Knoepfler, Ph.D. / 3 Comments

It’s a particularly exciting time for the stem cell field. One of the most notable developments in the last year or so is the production and preliminary study of a totally new type of human embryonic stem cells (ESC) made by nuclear transfer instead of using leftover in vitro fertilization (IVF) embryos. This process of so-called …

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Future of Somatic Cell Nuclear Transfer to make ES Cells

November 9, 2014 February 1, 2021 / By Professor Paul Knoepfler, Ph.D. / 3 Comments

Advances in therapeutic cloning reported in the past year have been very exciting as somatic cell nuclear transfer (SCNT) can be used to produce very powerful human embryonic stem cells (ESC). These new cells are called NT-ESCs for short. Neither embryos nor reprogramming factors are needed to produce human NT-ESCs. See here, here and here for discussions of the pioneering papers reporting creation of …

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Stem Cell Person of the Year Award 2014 Voting: Who Will Be Finalists?

October 15, 2014 December 22, 2023 / By Professor Paul Knoepfler, Ph.D.

With one week left to vote to pick the top 12 finalists for the Stem Cell Person of the Year 2014 Award, we have more than 2,800 votes in so far. From the top 12 vote-getters, I will choose the winner. This is the third year of this award. I self-fund this award out of …

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