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How Scott Gottlieb may transform the FDA’s approach to stem cells

March 14, 2017 / Professor Paul Knoepfler, Ph.D. / 2 Comments

The Trump FDA commissioner nominee Dr. Scott Gottlieb could dramatically alter how the agency regulates investigational stem cell therapies. How might such changes unfold? There are potential upsides and downsides to the seismic shift that could be in the offing. Gottlieb has written in the past about his perception of FDA over-regulation of stem cells such […]

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Perspectives on pig human chimera paper

January 26, 2017 / Professor Paul Knoepfler, Ph.D. / 12 Comments

A new paper focused on human and other chimeras just came out today in Cell reporting a number of findings, but most strikingly successful generation of human-pig chimeras in utero. The paper, entitled, “Interspecies Chimerism with Mammalian Pluripotent Stem Cells” describes various chimeras including mouse-rat ones, although those have previously been reported. This work comes

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Stem Cell Meetings & Conferences 2017

September 2, 2016 / Professor Paul Knoepfler, Ph.D.

Here is a hub for 2017 stem cell and regenerative medicine meetings. If you do not see your meeting, please let me know and I will include it. Change– I’m also going to be listing online courses (in red) this year. This list is meant to be as inclusive as possible, but by listing specific

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Gaetan Burgio New Data & Theory on NgAgo versus CRISPR

July 31, 2016 / Professor Paul Knoepfler, Ph.D. / 3 Comments

By Gaetan Burgio CRISPR/Cas9 genome editing has dramatically changed our way to perform biological experiments. While highly efficient and easy to use, one limitation with CRISPR/Cas9 mediated genome editing technology is the occurrence of off-target effects and the restriction of the PAM recognition sequence. Many modifications from the original system have been proposed to improve

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CRISPR Update: Patents, Embryos, & IPOs

April 13, 2016 / Professor Paul Knoepfler, Ph.D.

It’s been a busy few weeks for the CRISPR arena so I’ve made a CRISPR Update. I’ve listed below links to some commentaries and key developments. CRISPR update Fun Video interview on Read Science! with Joanne Manaster on my new book on CRISPR in humans, GMO Sapiens. CRISPR: Pursuit of profit poisons collaboration, Nature piece by Jacob Sherkow HIV

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New Paper on CRISPR of Human Embryos Highlights Serious Tech Problems

April 8, 2016 / Professor Paul Knoepfler, Ph.D. / 2 Comments

A new paper was recently published on CRISPR of human embryos for genetic modification. I’ve got to read this publication more carefully, but here’s a quick initial take on this human CRISPR 2.0 study. The paper is Kang, et al. and is entitled “Introducing precise genetic modifications into human 3PN embryos by CRISPR/Cas-mediated genome editing”.

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CRISPR embryo OK signals ongoing liberal UK trend on human modification

February 1, 2016 / Professor Paul Knoepfler, Ph.D. / 5 Comments

With the approval today of the use of CRISPR in human embryos, the UK continues its recent trend toward a more permissive regulatory policy on human genetic modification. There are both risks and scientific benefits that come along with this trend. Last year the UK approved an experimental technology with the goal of preventing the

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Join discussion of my new book GMO Sapiens on Talking Biopolitics tomorrow

January 25, 2016 / Professor Paul Knoepfler, Ph.D. / 2 Comments

I’ll be on Talking Biopolitics live tomorrow to discuss my new book, GMO Sapiens. You can RSVP at that link. You can get the Kindle version of the book here or the soft or cover versions at the publisher site here. Nathaniel Comfort will be interviewing me on the book and we’ll also be taking

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Patent expert weighs in on CRISPR dispute between UC & Broad

January 19, 2016 / Professor Paul Knoepfler, Ph.D. / 19 Comments

The patent dispute on CRISPR between UC/Jennifer Doudna and The Broad/Feng Zhang has been the subject of major attention including in a recent piece on Stanford Center for Law & Biosciences Blog. There is a lot of confusion over this important CRISPR dispute so I turned to a patent expert for their take on this via an interview

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