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My new Cell Stem Cell piece: too much carrot & not enough stick on stem cell oversight

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carrot-and-sticks

I have a new Cell Stem Cell piece out today that aims to take stock of today’s stem cell regulatory oversight in the U.S., Japan, and elsewhere including Australia, Canada and India. I use a carrot and stick metaphor for encouraging legit research and taking regulatory action on serious non-compliant activities, respectively. Where is stem cell […]

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List of regenerative medicine & stem cell meetings for rest of 2018

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Stem-cell-meetings-2018

This post contains a list of the remaining regenerative medicine and stem cell meetings for 2018. If you are interested in history, here’s our first ever meetings list for way back in 2012. Here’s the 2018 list. 10th World Congress and Expo on Cell & Stem Cell Research, NY, NY USA, March 19-21, 2018. iPSCs: A

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Mesoblast gets FDA RMAT; List of 10 total designations so far

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Mesoblast-e1514313188176

Australian stem cell biotech Mesoblast announced that it has received regenerative medicine advanced therapy (RMAT) designation from the U.S. FDA. This is very good news for the company and an encouraging development for the field. Interestingly, last month the FDA clarified that there is expanded RMAT designation that can include gene therapies too. At the Meeting

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Doubts raised on key points of Nature paper on CRISPR gene editing of human embryos

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Egli-Mitalipov-preprint

Is it possible that CRISPR gene editing actually didn’t happen in many of the human embryos in that big Nature paper that made such news a couple weeks back? Some doubts have emerged that call the main conclusions of the paper into question and argue that more definitive studies are needed to be sure. An

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How risky are stem cell trials for Parkinson’s beginning in China?

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Brain-PET-scan, stem cells

New human clinical trials using derivatives of pluripotent stem cells in China for Parkinson’s Disease (PD) have raised expectations and some eyebrows. PD is a neurodegenerative condition, sometimes diagnosed or followed by PET scans such as the one at left, characterized by loss of dopaminergic neurons leading to severe and sometimes life-threatening symptoms. Pluripotent stem

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Journal club review of new CRISPR ‘lots of off-target activity’ mouse paper

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CRISPR-mutations-Figure-1a

A new, brief study in mice from the Vinit Mahajan lab argues CRISPR can have very large numbers of off-target sites. Their paper is entitled “Unexpected mutations after CRISPR–Cas9 editing in vivo” and was published in Nature Methods.This work has garnered a lot of attention in the media. Let’s take a journal club review kind of approach

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