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Regenerative reads: brain organoids, Clinicaltrials.gov change

February 28, 2021 / Professor Paul Knoepfler, Ph.D. / 1 Comment

Sometimes change takes a very long time, but with brain organoids or advocating for better information for patients at Clinicaltrials.gov, after waiting you can see some interesting developments. These are two of the regenerative medicine stories of the week, along with some striking research papers. Clinicaltrials.gov Some of us have been advocating for improvements at […]

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Mesenchymal cells or MSCs: definition, clinical potential, challenges

February 8, 2021 / Professor Paul Knoepfler, Ph.D. / 16 Comments

mesenchymal cells, MSCs, mesenchymal stem cells, multipotent stem cells

I confess that I’m old enough to remember when the acronym MSC stood unambiguously for “mesenchymal stem cells”, but should it refer to a broader term like “mesenchymal cells”? The field has moved in that direction. I think that’s the best way to go too and I’ll explain why. The goal of today’s post is

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What are induced pluripotent stem cells or IPS cells?

January 25, 2021 / Professor Paul Knoepfler, Ph.D. / 6 Comments

induced pluripotent stem cells clinical trials map

Induced pluripotent stem cells or iPS cells just might be the most exciting development in the stem cell field over the last 15 years. They have unique potential for clinical impact for regenerative medicine too. This may manifest both through their use to produce differentiated cellular therapies and indirectly via disease modeling as well as

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Weekly reads & paper of the week: gene-editing vs. aging

January 10, 2021 / Professor Paul Knoepfler, Ph.D. / Leave a Comment

koblan et al 2020 nature gene editing progeria

The paper of the week reports using base-editing, a kind of gene-editing, to reverse mutations associated with rapid aging syndromes, generally called progeria, but there are a lot of other interesting pubs to recommend for reading this week. I go over it all in this post. Gene-editing to fight premature aging syndromes In vivo base

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Can Gene-Edited Stem Cells Treat Cystic Fibrosis?

September 28, 2020 / Ricki Lewis / Leave a Comment

human-IPS-cells-made-in-Knoeplfer-lab-stained-for-TRA-160

Drugs that restore the shape of the errant protein behind cystic fibrosis (CF) have, over the past eight years, helped the majority of patients, who have certain mutations. Gene-corrected stem cells might offer a “mutation agnostic” option to CF. CF results from a glitch in a glycoprotein with the unwieldy name “cystic fibrosis transmembrane conductance

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Weekly reads: lab meat, crow brain biology, direct reprogramming, more

September 27, 2020 / Professor Paul Knoepfler, Ph.D. / Leave a Comment

Does time seem somewhat warped to anyone else in 2020 even without having had COVID, which could alter brain function? It just seems like with everything going on that time simultaneously both drags and zooms by this year. One sort of reassuring element is that papers keep on being published so we can enjoy cool

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Recommended recent stem cell, cancer, & CRISPR reads

February 23, 2020 / Professor Paul Knoepfler, Ph.D. / 1 Comment

Eyleen-de-Poel-and-Maarten-Geurts.-Image-from-UMC-Utrecht.

What’s on your weekend reads list including stem cell papers? In addition to hard-core research papers, I find some bigger picture publications to be helpful too. Then there are just fun items. Every so often I do a post about things that I’m hoping to find time to read over the weekend or that I’ve

MUSE cells are in 4 Japanese stem cell trials despite doubts

November 17, 2019 / Professor Paul Knoepfler, Ph.D. / 16 Comments

Professor-Mari-Dezawa-talking-about-MUSE-cells-on-national-TV-in-Japan.-Screenshot.

The stem cell universe is populated by sometimes mysterious acronyms (see an image of a whole alphabet stem cell acronym soup), many of which refer to specific kinds of stem cells including one nebulous type called MUSE cells. MUSE cells clinical trials I’m not convinced that MUSE cells exist, but oddly there appear to be

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What is stromal vascular fraction or SVF?

July 21, 2019 / Professor Paul Knoepfler, Ph.D. / 26 Comments

When people discuss “fat stem cells” they usually mean “stromal vascular fraction” or SVF. While references to fat or adipose stem cells can sometimes mean non-SVF materials, these days adipose SVF gets the most attention. But, does anyone have a clear picture of this biologic? Fortunately, it’s starting to come more into focus in recent years

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