Search Results for: scnt

The Odd Couple of Cloning Research: Mitalipov & Woo Suk Hwang Unite

Hwang-Mitalipov

Remember that old TV show the Odd Couple with very proper Felix Unger and his polar opposite Oscar Madison who has all kinds of baggage? They’ve cloned it into a remake to be on TV soon here in the US in 2015. It seems only fitting then that actual human cloning research has a new …

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Future of Somatic Cell Nuclear Transfer to make ES Cells

NT-ESC-versus-IPSC

Advances in therapeutic cloning reported in the past year have been very exciting as somatic cell nuclear transfer (SCNT) can be used to produce very powerful human embryonic stem cells (ESC). These new cells are called NT-ESCs for short. Neither embryos nor reprogramming factors are needed to produce human NT-ESCs. See here, here and here for discussions of the pioneering papers reporting creation of …

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Review of Mitalipov Nature paper: cloned ES cells vs iPS cells

NT-ESC

Just how good are human embryonic stem (ES) cells made by therapeutic cloning via nuclear transfer, with the successful technique first reported by the lab of Shoukhrat Mitalipov at OHSU last year? How do they compare to induced pluripotent stem (iPS) cells or traditional ES cells made from IVF embryos? A new paper in Nature directly tackles these …

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Poll indicates that STAP cells are stem cell story of 2014 so far

stem-cell-polls-2014

What’s the biggest stem cell story of the year so far? I did a poll asking just that and the result so far overwhelmingly indicate that respondents believe the STAP cell scandal to be the top stem cell story of 2014 about half way through the year. You can see the results from the 210+ …

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Cool Cell Stem Cell Paper From Ishii Team on Histones & Reprogramming

Two of my favorite things are stem cells and histones. When they both come together in one paper and it’s in my favorite journal, Cell Stem Cell, you’ve got my full attention. My own lab is especially interested in the roles of histones and Myc in stem cells. So when I saw a paper a paper from …

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Nature Post-Pub Examination of Its Own STAP Stem Cell Papers Breaks New Ground

Nature

What’s the latest surprise on the STAP stem cell front? There have been many unexpected turn along the way in the past few weeks of the rollercoaster ride the stem cell field is on related to STAP stem cells, the super powerful stem cells reportedly (in two papers in Nature) made “simply” by exposing cells …

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Stem cell story of the year: human therapeutic cloning

Knoepfler-art-Human-Cloning

There have been many interesting developments in stem cells in 2013, but to me the biggest event by far was the first ever successful somatic cell nuclear transfer (SCNT)-based human therapeutic cloning. This approach generated apparently genetically normal human embryonic stem cells (hESC), an astonishing accomplishment. There are two kinds of human cloning: therapeutic and reproductive. …

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